{"id":"f7f7035d-5fdd-5254-b455-1ddcb50a4d77","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-human-hcy","predicate":"increases","statement":"At 4-5 hours after dosing, plasma total homocysteine was 12% higher than placebo, a 1.2 micromol/L difference (95% CI 0.6-1.7).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"99bda265-8dc3-5877-bd5b-20074ec87fb9","mechanism_event_label":"The methylation connection has a human biomarker result at a high dose.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"99bda265-8dc3-5877-bd5b-20074ec87fb9","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-human-hcy-event","event_type":"observed_intervention","label":"The methylation connection has a human biomarker result at a high dose.","description":"At 4-5 hours after dosing, plasma total homocysteine was 12% higher than placebo, a 1.2 micromol/L difference (95% CI 0.6-1.7).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/11237928.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b141ca7b40578ff2c375240255347999acc1d82cf721d117c96ff1a057d667e2\", \"start_char\": 0, \"end_char\": 1765, \"text_sha256\": \"b141ca7b40578ff2c375240255347999acc1d82cf721d117c96ff1a057d667e2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized-order four-period crossover in 20 adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2 g/day CGA for 7 days versus placebo; black tea and rutin comparator periods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High supplemental exposure. Homocysteine is a biomarker; this study did not establish cardiovascular harm, depletion of folate/B12/B6, or failure of the methylation cycle.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The methylation connection has a human biomarker result at a high dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p11237928] Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11237928/ DOI: 10.1093/ajcn/73.3.532","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma total homocysteine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"faa14c43-7d0c-5fd2-9af9-93a41836a115","evidence_kind":"source_excerpt","locator":"Lines 867-878","start_line":867,"end_line":878,"excerpt":"### chlorogenic_acid-human-hcy\nAt 4-5 hours after dosing, plasma total homocysteine was 12% higher than placebo, a 1.2 micromol/L difference (95% CI 0.6-1.7).\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The methylation connection has a human biomarker result at a high dose.\norganism: Human\ntissue_or_cell_type: Plasma total homocysteine\nexperimental_model: Randomized-order four-period crossover in 20 adults\nlimitations: High supplemental exposure. Homocysteine is a biomarker; this study did not establish cardiovascular harm, depletion of folate/B12/B6, or failure of the methylation cycle.\nexposure: 2 g/day CGA for 7 days versus placebo; black tea and rutin comparator periods\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/11237928.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b141ca7b40578ff2c375240255347999acc1d82cf721d117c96ff1a057d667e2\", \"start_char\": 0, \"end_char\": 1765, \"text_sha256\": \"b141ca7b40578ff2c375240255347999acc1d82cf721d117c96ff1a057d667e2\"}\n[chlorogenic_acid-p11237928] Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11237928/ DOI: 10.1093/ajcn/73.3.532","model_system":"Randomized-order four-period crossover in 20 adults","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chlorogenic_acid-p11237928] Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11237928/ DOI: 10.1093/ajcn/73.3.532","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"98a7cb8d-1d80-5cfe-9690-4068d21878e3","stable_key":"import-00c24cfe-6189-5244-b81f-5d693e4e177d","title":"Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"dabd56b55fb10d82913b222343d9592d3baf61ef3cc81cf47f3e3e7537eb7992","revision_id":"340aee2f-52a6-56aa-99c1-0a24c534752a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}