{"id":"f7578bdb-8fbe-5b2e-a916-ca93eb113c30","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-valproate-timecourse","predicate":"changes_over_time","statement":"In the patient observed when starting valproate, plasma carnitine fell during weeks 1-3 and recovered by weeks 3-5.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"25c523f2-1609-5e6b-92d4-786b31673059","mechanism_event_label":"Drug-associated carnitine changes can evolve over time.","subject":{"id":"fb306afa-9cb8-5395-8fca-3e8c170c5635","slug":"valproate","display_name":"Valproate","entity_type_key":"small_molecule"},"object":{"id":"ff8385ac-e32c-59f8-8d30-2f8244367ba8","slug":"human-valproate-plasma-carnitine","display_name":"Human plasma carnitine during valproate therapy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"25c523f2-1609-5e6b-92d4-786b31673059","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-valproate-timecourse-event","event_type":"observed_relationship","label":"Drug-associated carnitine changes can evolve over time.","description":"In the patient observed when starting valproate, plasma carnitine fell during weeks 1-3 and recovered by weeks 3-5.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fb306afa-9cb8-5395-8fca-3e8c170c5635","slug":"valproate","display_name":"Valproate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ff8385ac-e32c-59f8-8d30-2f8244367ba8","slug":"human-valproate-plasma-carnitine","display_name":"Human plasma carnitine during valproate therapy","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"One longitudinal initiation case plus ten long-term patients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Suppressed synthesis and increased OCTN2 expression were proposed explanations, not directly measured human mechanisms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Drug-associated carnitine changes can evolve over time.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22743351/ · DOI 10.1097/FTD.0b013e3182608e2f","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b9ff3f43-8b17-547f-b17b-1459617fb204","evidence_kind":"source_excerpt","locator":"Lines 282-288","start_line":282,"end_line":288,"excerpt":"## l-carnitine-valproate-timecourse\nDrug-associated carnitine changes can evolve over time.\nIn the patient observed when starting valproate, plasma carnitine fell during weeks 1-3 and recovered by weeks 3-5.\nModel: One longitudinal initiation case plus ten long-term patients.\nLimitations: Suppressed synthesis and increased OCTN2 expression were proposed explanations, not directly measured human mechanisms.\nEvidence access: Primary abstract\nEffect of short- and long-term treatment with valproate on carnitine homeostasis in humans. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22743351/ · DOI 10.1097/FTD.0b013e3182608e2f","model_system":"One longitudinal initiation case plus ten long-term patients.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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