{"id":"f749e58f-d6b5-5e58-96bc-f9e090f86341","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-astrocyte-shuttle","predicate":"supplies_serine_for","statement":"Astrocytic Phgdh inhibition reduced newly synthesized L- and D-serine; neuronal serine-racemase deletion reduced D-serine synthesis to a similar extent.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"72f05163-c5ae-5bb6-883a-16cf549aec1c","mechanism_event_label":"Support cells can supply precursor while neurons perform the final conversion.","subject":{"id":"0facfd8d-0764-54d6-9818-14907ca6b25d","slug":"mouse-phgdh","display_name":"Mouse phosphoglycerate dehydrogenase / Phgdh","entity_type_key":"protein"},"object":{"id":"30de8765-6d0c-5477-a40f-f620a8a96fa0","slug":"mouse-neuronal-d-serine-synthesis","display_name":"New D-serine synthesis in mouse neurons","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"72f05163-c5ae-5bb6-883a-16cf549aec1c","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-astrocyte-shuttle-event","event_type":"observed_relationship","label":"Support cells can supply precursor while neurons perform the final conversion.","description":"Astrocytic Phgdh inhibition reduced newly synthesized L- and D-serine; neuronal serine-racemase deletion reduced D-serine synthesis to a similar extent.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0facfd8d-0764-54d6-9818-14907ca6b25d","slug":"mouse-phgdh","display_name":"Mouse phosphoglycerate dehydrogenase / Phgdh","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"30de8765-6d0c-5477-a40f-f620a8a96fa0","slug":"mouse-neuronal-d-serine-synthesis","display_name":"New D-serine synthesis in mouse neurons","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ad4f7e6e-2d43-5d8b-9b79-24b8a65777c6","slug":"mouse-srr","display_name":"Mouse serine racemase / Srr","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7f3bf9f5-b1b1-5381-baa6-72800ceb5436","slug":"d-serine","display_name":"D-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse genetic and hippocampal experiments with synthesis measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not establish exclusive cell-type localization under every developmental or disease condition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Support cells can supply precursor while neurons perform the final conversion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31548413/ · DOI 10.1073/pnas.1909458116","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f093a8cf-8c24-5370-a83d-f47f5919381e","evidence_kind":"source_excerpt","locator":"Lines 342-348","start_line":342,"end_line":348,"excerpt":"## l-serine-astrocyte-shuttle\nSupport cells can supply precursor while neurons perform the final conversion.\nAstrocytic Phgdh inhibition reduced newly synthesized L- and D-serine; neuronal serine-racemase deletion reduced D-serine synthesis to a similar extent.\nModel: Mouse genetic and hippocampal experiments with synthesis measurements.\nLimitations: This does not establish exclusive cell-type localization under every developmental or disease condition.\nEvidence access: Primary abstract\nThe NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31548413/ · DOI 10.1073/pnas.1909458116","model_system":"Mouse genetic and hippocampal experiments with synthesis measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70bcf57a-36bb-563f-9073-2d616e5f155a","stable_key":"import-649e861b-265a-5912-bc36-3a73e53ef892","title":"L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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