{"id":"f728fce4-f797-55f8-8bf4-7b738f7a3b72","stable_key":"8600a864-6653-52c7-9718-1362c5af4577:gamma-nonalactone-sucrose-aroma-threshold","predicate":"has_detection_threshold","statement":"The gamma-nonalactone aroma detection threshold in 5% sucrose was reported as 0.0047 mg/kg solution.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"c8f81ae7-9210-5a6c-ad11-369e1b8662f2","mechanism_event_label":"The gamma-nonalactone aroma detection threshold in 5% sucrose was reported as 0.0047 mg/kg solution.","subject":{"id":"2b85fa4a-5c91-5de9-aead-a443bc4394af","slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"},"object":{"id":"b303bee8-2600-5cbf-8a5f-2d03cbcf8539","slug":"human-gamma-nonalactone-odor-detection","display_name":"Human gamma-nonalactone aroma detection","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c8f81ae7-9210-5a6c-ad11-369e1b8662f2","stable_key":"8600a864-6653-52c7-9718-1362c5af4577:gamma-nonalactone-sucrose-aroma-threshold-event","event_type":"observed_relationship","label":"The gamma-nonalactone aroma detection threshold in 5% sucrose was reported as 0.0047 mg/kg solution.","description":"The gamma-nonalactone aroma detection threshold in 5% sucrose was reported as 0.0047 mg/kg solution.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b85fa4a-5c91-5de9-aead-a443bc4394af","slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b303bee8-2600-5cbf-8a5f-2d03cbcf8539","slug":"human-gamma-nonalactone-odor-detection","display_name":"Human gamma-nonalactone aroma detection","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Gamma-nonalactone serial dilution; reported threshold 0.0047 mg/kg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Repeated threshold trials","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results inspected; PubMed metadata where indexed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten trained human sensory evaluators","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The water comparison was a literature reference, not a matched experiment. Do not equate detection threshold with the much larger sweetness-optimization concentration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gamma-nonalactone flavor-compound chapter; nutrient and drug interactions retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Ten trained human sensory evaluators","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The gamma-nonalactone aroma detection threshold in 5% sucrose was reported as 0.0047 mg/kg solution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sweetness enhancement and mechanism by sweet aroma compounds in the sucrose solution using sensory, electronic tongue, molecular docking, and molecular dynamics simulation. (2026). https://pubmed.ncbi.nlm.nih.gov/41884462/ DOI: 10.1016/j.fochx.2026.103753","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Sensory testing in sucrose solution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Three-alternative forced-choice aroma detection in 5% sucrose","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d92ccb5b-a926-5610-a53f-4ce811a9f47a","evidence_kind":"source_excerpt","locator":"Lines 246-255","start_line":246,"end_line":255,"excerpt":"## gamma-nonalactone-sucrose-aroma-threshold\nThe gamma-nonalactone aroma detection threshold in 5% sucrose was reported as 0.0047 mg/kg solution.\nModel/species: Ten trained human sensory evaluators\nTissue: Three-alternative forced-choice aroma detection in 5% sucrose\nExposure: Gamma-nonalactone serial dilution; reported threshold 0.0047 mg/kg\nRoute: Sensory testing in sucrose solution\nDuration: Repeated threshold trials\nLimits: The water comparison was a literature reference, not a matched experiment. Do not equate detection threshold with the much larger sweetness-optimization concentration.\nPrimary reference: Sweetness enhancement and mechanism by sweet aroma compounds in the sucrose solution using sensory, electronic tongue, molecular docking, and molecular dynamics simulation. (2026). https://pubmed.ncbi.nlm.nih.gov/41884462/ DOI: 10.1016/j.fochx.2026.103753\nAccess: Primary full-text methods/results inspected; PubMed metadata where indexed.","model_system":"Ten trained human sensory evaluators","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73777c54-95a4-5b07-9d14-d4dd31949fb1","stable_key":"import-8600a864-6653-52c7-9718-1362c5af4577","title":"Gamma-nonalactone: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eight primary studies. Study-specific citations, negative findings and limitations retained. 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