{"id":"f6dbc5ca-1dba-5f04-9935-aa367df99d47","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-phase2","predicate":"minimally_changes_overall","statement":"Overall lymphocyte GST and bilirubin-based UGT1A1 indices changed minimally after resveratrol, with larger changes reported in low-baseline subgroups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"636d0554-4b89-5129-8a91-937434e684a9","mechanism_event_label":"A subgroup signal is not a universal detoxification effect.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"232c4dd6-b374-58ae-b048-6e9b79cbcc91","slug":"human-resveratrol-phase2-enzyme-indices","display_name":"Human phase-II enzyme indices after resveratrol","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"636d0554-4b89-5129-8a91-937434e684a9","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-phase2-event","event_type":"observed_relationship","label":"A subgroup signal is not a universal detoxification effect.","description":"Overall lymphocyte GST and bilirubin-based UGT1A1 indices changed minimally after resveratrol, with larger changes reported in low-baseline subgroups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"232c4dd6-b374-58ae-b048-6e9b79cbcc91","slug":"human-resveratrol-phase2-enzyme-indices","display_name":"Human phase-II enzyme indices after resveratrol","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a54855e7-1ba5-5d14-8c14-70f06248ae5a","slug":"ugt1a1","display_name":"Human UDP-glucuronosyltransferase 1A1 / UGT1A1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same four-week volunteer study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Bilirubin was a surrogate; this was not a direct hepatic UGT flux measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A subgroup signal is not a universal detoxification effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20716633/ · DOI 10.1158/1940-6207.CAPR-09-0155","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"85ce68d5-634b-5c16-b309-46514da8d1f7","evidence_kind":"source_excerpt","locator":"Lines 446-452","start_line":446,"end_line":452,"excerpt":"## resveratrol-human-phase2\nA subgroup signal is not a universal detoxification effect.\nOverall lymphocyte GST and bilirubin-based UGT1A1 indices changed minimally after resveratrol, with larger changes reported in low-baseline subgroups.\nModel: Same four-week volunteer study.\nLimitations: Bilirubin was a surrogate; this was not a direct hepatic UGT flux measurement.\nEvidence access: Primary abstract\nResveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20716633/ · DOI 10.1158/1940-6207.CAPR-09-0155","model_system":"Same four-week volunteer study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}