{"id":"f676cfa2-0771-56e6-90ca-9058452cb8c9","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-sgk-foxo","predicate":"inactivates","statement":"The study identified SGK1-dependent deactivation of Foxo1 in the TH17 program.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"856adee1-ccf9-52e9-ab39-adaf8328e138","mechanism_event_label":"The same kinase family used in kidney salt handling has another role in immune cells.","subject":{"id":"4db8cea5-2f5d-5df0-881a-a725d1920e85","slug":"sgk1","display_name":"Serum and glucocorticoid-regulated kinase 1","entity_type_key":"protein"},"object":{"id":"f21a8b7c-4b28-532f-b401-0d3a29fcde76","slug":"mouse-foxo1","display_name":"Mouse forkhead transcription factor Foxo1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"856adee1-ccf9-52e9-ab39-adaf8328e138","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-sgk-foxo-event","event_type":"biochemical_relationship","label":"The same kinase family used in kidney salt handling has another role in immune cells.","description":"The study identified SGK1-dependent deactivation of Foxo1 in the TH17 program.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fc7af404-f450-502d-98e1-904bc3e8fffc","slug":"il23","display_name":"Interleukin-23","entity_type_key":"protein_complex"},"role":"upstream_signal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4db8cea5-2f5d-5df0-881a-a725d1920e85","slug":"sgk1","display_name":"Serum and glucocorticoid-regulated kinase 1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f21a8b7c-4b28-532f-b401-0d3a29fcde76","slug":"mouse-foxo1","display_name":"Mouse forkhead transcription factor Foxo1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/23467085.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"25fdc34faa9d6f0b84dfc9daf98ecc8e09f2486853b9e99bdae552e5ca8c5b2e\", \"start_char\": 0, \"end_char\": 1656, \"text_sha256\": \"25fdc34faa9d6f0b84dfc9daf98ecc8e09f2486853b9e99bdae552e5ca8c5b2e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"T-cell transcriptional profiling, kinase loss and experimental autoimmune assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"NaCl elevation and Sgk1 perturbation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The SGK1–Foxo1–IL23R pathway is scoped to this immune-cell program, not universal sodium action.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same kinase family used in kidney salt handling has another role in immune cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p23467085] Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. (2013). https://pubmed.ncbi.nlm.nih.gov/23467085/ DOI: 10.1038/nature11984","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"IL-23-responsive TH17 cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1998d14c-196e-5e75-9ede-a1122287417b","evidence_kind":"source_excerpt","locator":"Lines 551-562","start_line":551,"end_line":562,"excerpt":"### sodium-sgk-foxo\nThe study identified SGK1-dependent deactivation of Foxo1 in the TH17 program.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The same kinase family used in kidney salt handling has another role in immune cells.\norganism: Mouse\ntissue_or_cell_type: IL-23-responsive TH17 cells\nexperimental_model: T-cell transcriptional profiling, kinase loss and experimental autoimmune assays\nlimitations: The SGK1–Foxo1–IL23R pathway is scoped to this immune-cell program, not universal sodium action.\nexposure: NaCl elevation and Sgk1 perturbation\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/23467085.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"25fdc34faa9d6f0b84dfc9daf98ecc8e09f2486853b9e99bdae552e5ca8c5b2e\", \"start_char\": 0, \"end_char\": 1656, \"text_sha256\": \"25fdc34faa9d6f0b84dfc9daf98ecc8e09f2486853b9e99bdae552e5ca8c5b2e\"}\n[sodium-p23467085] Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. 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