{"id":"f6759f60-4992-571e-a9b3-b4840271d3b9","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-trpv1-gating","predicate":"activates","statement":"Capsaicin activates TRPV1, a nonselective cation channel that is also activated by noxious heat.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"04fb98aa-c778-5a84-b248-181ac13b24b7","mechanism_event_label":"Capsaicin activates TRPV1, a nonselective cation channel that is also activated by noxious heat.","subject":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"object":{"id":"8e0c61d8-3930-51d5-bce2-25a5edfb797c","slug":"human-trpv1","display_name":"Human transient receptor potential vanilloid 1 / TRPV1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"04fb98aa-c778-5a84-b248-181ac13b24b7","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-trpv1-gating-event","event_type":"observed_relationship","label":"Capsaicin activates TRPV1, a nonselective cation channel that is also activated by noxious heat.","description":"Capsaicin activates TRPV1, a nonselective cation channel that is also activated by noxious heat.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e0c61d8-3930-51d5-bce2-25a5edfb797c","slug":"human-trpv1","display_name":"Human transient receptor potential vanilloid 1 / TRPV1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Capsaicin concentration-response and noxious-range temperature","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cloned capsaicin receptor expressed from sensory-neuron cDNA","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The cloned receptor experiment establishes channel gating, not the whole organism response to chili foods.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Capsaicin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cloned capsaicin receptor expressed from sensory-neuron cDNA","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Capsaicin activates TRPV1, a nonselective cation channel that is also activated by noxious heat.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The capsaicin receptor: a heat-activated ion channel in the pain pathway. (1997). https://pubmed.ncbi.nlm.nih.gov/9349813/ DOI: 10.1038/39807","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Calcium influx and heat activation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e17c3ffb-cefc-5242-8987-9fbf5fde1d4a","evidence_kind":"source_excerpt","locator":"Lines 11-20","start_line":11,"end_line":20,"excerpt":"## capsaicin-trpv1-gating\nCapsaicin activates TRPV1, a nonselective cation channel that is also activated by noxious heat.\nModel/species: Cloned capsaicin receptor expressed from sensory-neuron cDNA\nTissue/system: Calcium influx and heat activation\nExposure: Capsaicin concentration-response and noxious-range temperature\nRoute: In vitro\nDuration: Acute\nLimits: The cloned receptor experiment establishes channel gating, not the whole organism response to chili foods.\nPrimary reference: The capsaicin receptor: a heat-activated ion channel in the pain pathway. (1997). https://pubmed.ncbi.nlm.nih.gov/9349813/ DOI: 10.1038/39807\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Cloned capsaicin receptor expressed from sensory-neuron cDNA","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"883c8afb-af48-5561-ae3b-00d4f3c26752","stable_key":"import-49fecf36-4958-5f15-8c78-9a68cba50763","title":"Capsaicin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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