{"id":"f6663499-1a32-5920-83de-e763339ac943","stable_key":"2921131d-0ba0-51d3-8f59-8c4be3b9ac08:cucurbitacin-b-bso-sensitivity","predicate":"increases_tested","statement":"Pretreating human NSCLC cells with the glutathione-synthesis inhibitor BSO increased cucurbitacin B cytotoxicity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c8d0382f-d373-5d37-9855-dc6d835c8298","mechanism_event_label":"Weakening glutathione production increased sensitivity in this model.","subject":{"id":"522ac38a-0bc1-57fb-a1e5-45ca2c14515c","slug":"buthionine-sulfoximine","display_name":"L-Buthionine-S-sulfoximine / BSO","entity_type_key":"small_molecule"},"object":{"id":"2605a691-2bf7-5dd6-af15-d07e90d6aac2","slug":"human-cub-cytotoxicity","display_name":"Human NSCLC cytotoxic response to cucurbitacin B","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c8d0382f-d373-5d37-9855-dc6d835c8298","stable_key":"2921131d-0ba0-51d3-8f59-8c4be3b9ac08:cucurbitacin-b-bso-sensitivity-event","event_type":"observed_relationship","label":"Weakening glutathione production increased sensitivity in this model.","description":"Pretreating human NSCLC cells with the glutathione-synthesis inhibitor BSO increased cucurbitacin B cytotoxicity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"522ac38a-0bc1-57fb-a1e5-45ca2c14515c","slug":"buthionine-sulfoximine","display_name":"L-Buthionine-S-sulfoximine / BSO","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2605a691-2bf7-5dd6-af15-d07e90d6aac2","slug":"human-cub-cytotoxicity","display_name":"Human NSCLC cytotoxic response to cucurbitacin B","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a544a561-7647-55f6-8ba1-c7ab0133f968","slug":"cucurbitacin-b","display_name":"Cucurbitacin B","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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