{"id":"f651e05a-26f8-5d18-9422-307995ebe6cb","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-xo-superoxide","predicate":"reduces_enzyme_generated","statement":"Luteolin reduced superoxide production by purified bovine xanthine oxidase.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"943ee3d1-0573-55d2-8fd8-03e124af3146","mechanism_event_label":"Blocking the enzyme also reduced its radical output.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"011511ed-2be5-566d-bd1b-9d580dab1e9c","slug":"superoxide-anion","display_name":"Superoxide radical anion","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"943ee3d1-0573-55d2-8fd8-03e124af3146","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-xo-superoxide-event","event_type":"observed_relationship","label":"Blocking the enzyme also reduced its radical output.","description":"Luteolin reduced superoxide production by purified bovine xanthine oxidase.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"011511ed-2be5-566d-bd1b-9d580dab1e9c","slug":"superoxide-anion","display_name":"Superoxide radical anion","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8f0bfaa1-4efc-586c-bbf9-764de45f4d91","slug":"bovine-xdh","display_name":"Bovine xanthine oxidoreductase / XDH","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Bovine enzyme assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish antioxidant benefit across tissues.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Blocking the enzyme also reduced its radical output.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19388706/ · DOI 10.1021/np8007123","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"01a0da0e-9fbc-5d2e-86b3-1772c506c01e","evidence_kind":"source_excerpt","locator":"Lines 292-298","start_line":292,"end_line":298,"excerpt":"## luteolin-xo-superoxide\nBlocking the enzyme also reduced its radical output.\nLuteolin reduced superoxide production by purified bovine xanthine oxidase.\nModel: Bovine enzyme assays.\nLimitations: Does not establish antioxidant benefit across tissues.\nEvidence access: Primary abstract\nInhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19388706/ · DOI 10.1021/np8007123","model_system":"Bovine enzyme assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}