{"id":"f63aa827-b155-5854-9b4f-4572d988e00e","stable_key":"research:semet-functional","predicate":"supplies","statement":"SeMet supplementation increased functional selenium biomarkers including SELENOP and plasma GPX activity in selenium-deficient people.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:supported_interpretation","direction":"positive","is_public":true,"mechanism_event_id":"68964b70-c497-5be2-9eac-23ee0c2109e2","mechanism_event_label":"SeMet can supply functional selenium as well as enter protein storage.","subject":{"id":"9ae8a163-7137-5610-800b-82ef311e28b9","slug":"selenomethionine","display_name":"Selenomethionine (SeMet)","entity_type_key":"small_molecule"},"object":{"id":"5bc4ebf6-26cd-5e8d-b496-54465bb696bb","slug":"functional-selenium-pool","display_name":"Functional selenium precursor pool","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"68964b70-c497-5be2-9eac-23ee0c2109e2","stable_key":"research:semet-functional","event_type":"contextual_mechanism","label":"SeMet can supply functional selenium as well as enter protein storage.","description":"SeMet supplementation increased functional selenium biomarkers including SELENOP and plasma GPX activity in selenium-deficient people.","status":"active","compartment":null,"participants":[{"entity":{"id":"9ae8a163-7137-5610-800b-82ef311e28b9","slug":"selenomethionine","display_name":"Selenomethionine (SeMet)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5bc4ebf6-26cd-5e8d-b496-54465bb696bb","slug":"functional-selenium-pool","display_name":"Functional selenium precursor pool","entity_type_key":"chemical_species"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"Circulating biomarkers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized SeMet supplementation in selenium-deficient people","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Baseline-deficient population; not disease-prevention evidence in selenium-replete people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"313829e6-ab57-529e-9d6c-4ef454ab8e5e","evidence_kind":"curated_literature_summary","locator":"lines 1456-1466","start_line":1456,"end_line":1466,"excerpt":"## semet-functional\n\nSeMet can supply functional selenium as well as enter protein storage.\n\nSeMet supplementation increased functional selenium biomarkers including SELENOP and plasma GPX activity in selenium-deficient people.\n\nOrganism: Homo sapiens\nCell type: Circulating biomarkers\nExperimental model: Randomized SeMet supplementation in selenium-deficient people\nLimitations: Baseline-deficient population; not disease-prevention evidence in selenium-replete people.\nPrimary reference: [Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects](https://pubmed.ncbi.nlm.nih.gov/20573787/)","model_system":"Randomized SeMet supplementation in selenium-deficient people","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[{"id":"cd342eaa-b8d6-5b3e-bdf1-abcd2346cef6","title":"SeMet can supply functional selenium as well as protein storage","kind":"contradiction","status":"corrected","why":"The earlier draft labels SeMet an inactive storage form. The new reference includes conversion into the functional selenium pool and explicitly rejects the storage-only description.","resolution":"Model both metabolic destinations. Trial results cannot be attributed conclusively to formulation alone.","created_at":"2026-09-17 05:59:32","record_type":"correction","display_label":"Correction history","record_url":"/corrections/cd342eaa-b8d6-5b3e-bdf1-abcd2346cef6","literature_review":{"revision_id":"80984e03-5f0f-5877-8094-afef7637444e","start_line":1704,"end_line":1709,"papers":[{"paper_key":"xia-2010","title":"Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects","url":"https://pubmed.ncbi.nlm.nih.gov/20573787/","doi":null,"year":2010,"model":"Randomized SeMet supplementation in selenium-deficient people","summary":"SeMet raises functional SELENOP and plasma GPX biomarkers."}]},"sides":[{"conflict_id":"cd342eaa-b8d6-5b3e-bdf1-abcd2346cef6","ordinal":0,"label":"Earlier statement","revision_id":"4cec6304-35d7-5560-9133-e6ea689db838","start_line":300,"end_line":302,"quote":"**SeMet is a storage form, not an active one.** It has no selenium-specific recognition — methionyl-tRNA synthetase can't tell Se from S, so SeMet gets **incorporated nonspecifically into albumin, hemoglobin, every protein in the body** at the Met positions. It raises plasma selenium beautifully and delivers almost no methylselenol.\n\nSELECT gave a selenium-replete population a storage compound. It was a null result waiting to happen.","claim_id":null,"source_key":"corrections","source_title":"Selenium corrections and deep dive","claim_ids":[]},{"conflict_id":"cd342eaa-b8d6-5b3e-bdf1-abcd2346cef6","ordinal":1,"label":"New reference qualification","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","start_line":661,"end_line":681,"quote":"Selenomethionine (SeMet)\n\nWell absorbed; can enter the methionine pool and be nonspecifically incorporated into proteins, and can also be metabolized into the functional selenium pool\n\nSelenium-enriched yeast\n\nMixture of selenium compounds, usually dominated by SeMet; composition varies by product\n\nSodium selenite\n\nInorganic selenium; metabolized toward reduced selenium intermediates; thiol-reactive and kinetically distinct from SeMet\n\nSodium selenate\n\nInorganic selenium that requires reduction before entering central selenium metabolism\n\nSe-methylselenocysteine\n\nDistinct metabolism and substantial experimental pharmacology; not interchangeable with ordinary nutritional dosing\n\nCalling SeMet only “storage” and selenite only “functional” is too simple. Form changes pharmacokinetics and metabolism, but baseline status, dose, population, duration, endpoint, and study design also determine outcomes.","claim_id":null,"source_key":"deficiency","source_title":"Selenium deficiency: a mechanism-first reference","claim_ids":[]}]}],"research":{"topic":"Selenium scientific audit","plain_language":"SeMet can supply functional selenium as well as enter protein storage.","evidence_scope":"supported_interpretation","papers":[{"key":"xia-2010","title":"Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects","url":"https://pubmed.ncbi.nlm.nih.gov/20573787/","doi":null,"year":2010,"model":"Randomized SeMet supplementation in selenium-deficient people","summary":"SeMet raises functional SELENOP and plasma GPX biomarkers."}]}}