{"id":"f61ee50d-4a95-51f6-a8c5-744da9f89ea6","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vdm-calcitriol-increases-bone-fgf23-transcripts","predicate":"increases_expression","statement":"Calcitriol administration produced about a fourfold increase in bone Fgf23 transcripts in the Liu mouse study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"cc4ba794-b4ba-5c99-9fca-76f2b0828253","mechanism_event_label":"Active vitamin D induced a bone hormone that feeds back on vitamin D activation and phosphate handling.","subject":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"object":{"id":"e827e94a-6ba8-5326-9252-06aa615fba92","slug":"fgf23-mrna","display_name":"FGF23 mRNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"cc4ba794-b4ba-5c99-9fca-76f2b0828253","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vdm-calcitriol-increases-bone-fgf23-transcripts-event","event_type":"biochemical_relationship","label":"Active vitamin D induced a bone hormone that feeds back on vitamin D activation and phosphate handling.","description":"Calcitriol administration produced about a fourfold increase in bone Fgf23 transcripts in the Liu mouse study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"hormonal-regulator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d725020b-bacc-5e90-b370-cda246025c91","slug":"vdr","display_name":"Vitamin D receptor / VDR","entity_type_key":"protein"},"role":"receptor-context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6edbc5a6-fcb5-516d-9c86-66950a8984b3","slug":"fgf23","display_name":"Fibroblast growth factor 23 / FGF23","entity_type_key":"protein"},"role":"encoded-hormone","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b28dfc54-a5ef-5f9e-ac1f-890b68e58dc3","slug":"inorganic-phosphate","display_name":"Inorganic phosphate","entity_type_key":"chemical_species"},"role":"regulated-nutrient-context","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e827e94a-6ba8-5326-9252-06aa615fba92","slug":"fgf23-mrna","display_name":"FGF23 mRNA","entity_type_key":"rna"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Vitamin D–calcium–phosphate regulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_locator","value_text":"Abstract: reported experimental results","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"D3 active metabolite or VDR machinery experiment; not a direct D2-versus-D3 comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Calcitriol-injected mice; bone Fgf23 transcript assay and circulating FGF23 measurement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Calcitriol administration; circulating FGF23 rose by 8 hours. Dose and transcript collection time not specified in the retrieved abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The mRNA result is distinguished from circulating hormone and renal action; the separate cell reporter experiment supports receptor dependence but is not inferred to prove every bone enhancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient","value_text":"Vitamin D2 and D3","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Active vitamin D induced a bone hormone that feeds back on vitamin D activation and phosphate handling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[vdm-liu2006] Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. (2006). https://pubmed.ncbi.nlm.nih.gov/16597685/ DOI: 10.1681/asn.2005111185","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Bone","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e5580173-4a34-5548-89ce-e60247c9a2f5","evidence_kind":"source_excerpt","locator":"Lines 729-743","start_line":729,"end_line":743,"excerpt":"### vdm-calcitriol-increases-bone-fgf23-transcripts\nCalcitriol administration produced about a fourfold increase in bone Fgf23 transcripts in the Liu mouse study.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Active vitamin D induced a bone hormone that feeds back on vitamin D activation and phosphate handling.\norganism: Mus musculus\ntissue_or_cell_type: Bone\nexperimental_model: Calcitriol-injected mice; bone Fgf23 transcript assay and circulating FGF23 measurement\nlimitations: The mRNA result is distinguished from circulating hormone and renal action; the separate cell reporter experiment supports receptor dependence but is not inferred to prove every bone enhancer.\nexposure: Calcitriol administration; circulating FGF23 rose by 8 hours. Dose and transcript collection time not specified in the retrieved abstract.\ncross_nutrient: Vitamin D–calcium–phosphate regulation.\nevidence_locator: Abstract: reported experimental results\nnutrient: Vitamin D2 and D3\nevidence_scope: D3 active metabolite or VDR machinery experiment; not a direct D2-versus-D3 comparison.\n[vdm-liu2006] Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. (2006). https://pubmed.ncbi.nlm.nih.gov/16597685/ DOI: 10.1681/asn.2005111185","model_system":"Calcitriol-injected mice; bone Fgf23 transcript assay and circulating FGF23 measurement","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [vdm-liu2006] Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. (2006). https://pubmed.ncbi.nlm.nih.gov/16597685/ DOI: 10.1681/asn.2005111185","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}