{"id":"f61c9fef-f46e-5ebe-8873-95d2e829c1db","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-lugol-null","predicate":"no_significant_difference","statement":"A 2024 Lugol trial found no significant blood-loss difference, medians 80.5 versus 94 mL.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"721120ed-b138-5125-913c-03c787308711","mechanism_event_label":"A different iodine formulation did not reproduce the bleeding benefit.","subject":{"id":"244dc06e-ccb7-5a55-b59a-a19f88d90621","slug":"lugols-solution","display_name":"Lugol solution (iodine plus potassium iodide)","entity_type_key":"chemical_species"},"object":{"id":"e9b2b4c0-9325-5b8b-8843-5f8f40a1182d","slug":"thyroidectomy-blood-loss","display_name":"Blood loss during thyroidectomy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"721120ed-b138-5125-913c-03c787308711","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-lugol-null-event","event_type":"observed_relationship","label":"A different iodine formulation did not reproduce the bleeding benefit.","description":"A 2024 Lugol trial found no significant blood-loss difference, medians 80.5 versus 94 mL.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"244dc06e-ccb7-5a55-b59a-a19f88d90621","slug":"lugols-solution","display_name":"Lugol solution (iodine plus potassium iodide)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e9b2b4c0-9325-5b8b-8843-5f8f40a1182d","slug":"thyroidectomy-blood-loss","display_name":"Blood loss during thyroidectomy","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Seven-day Lugol regimen; 56 analyzed patients (29 treated, 27 controls).","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Lugol contains iodine plus KI and is not SSKI. Full flow chart reports 70 randomized and 14 intervention withdrawals; avoid treating 56 as the randomized total.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A different iodine formulation did not reproduce the bleeding benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Role of Lugol solution before total thyroidectomy for Graves' disease: randomized clinical trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39129619/ · DOI 10.1093/bjs/znae196","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"eb8fa6fd-a445-52db-aa9a-67a8c34f778b","evidence_kind":"source_excerpt","locator":"Lines 424-430","start_line":424,"end_line":430,"excerpt":"## ki-lugol-null\nA different iodine formulation did not reproduce the bleeding benefit.\nA 2024 Lugol trial found no significant blood-loss difference, medians 80.5 versus 94 mL.\nModel: Seven-day Lugol regimen; 56 analyzed patients (29 treated, 27 controls).\nLimitations: Lugol contains iodine plus KI and is not SSKI. Full flow chart reports 70 randomized and 14 intervention withdrawals; avoid treating 56 as the randomized total.\nEvidence location: Primary abstract plus trial flow diagram\nRole of Lugol solution before total thyroidectomy for Graves' disease: randomized clinical trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39129619/ · DOI 10.1093/bjs/znae196","model_system":"Seven-day Lugol regimen; 56 analyzed patients (29 treated, 27 controls).","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}