{"id":"f5e52639-a135-5008-a4cb-7a69d9d2c1df","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-msra-camkii-repair","predicate":"limits","statement":"Msra-null mice had greater CaMKII oxidation, myocardial apoptosis and post-infarction dysfunction; methionine-sulfoxide reduction reversed oxidation-dependent activation in supporting assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dd6556b5-062d-53eb-a891-af18440771ad","mechanism_event_label":"Repairing an oxidized residue can reset a signaling switch.","subject":{"id":"a7e2bb18-4af8-5b15-8a97-67e6c4b7483e","slug":"mouse-msra","display_name":"Mouse methionine sulfoxide reductase A / Msra","entity_type_key":"protein"},"object":{"id":"36197e24-51a3-549f-bb64-c87afee0cf13","slug":"mouse-oxidized-camkii-heart-injury","display_name":"Oxidized CaMKII and cardiac injury in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dd6556b5-062d-53eb-a891-af18440771ad","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-msra-camkii-repair-event","event_type":"observed_relationship","label":"Repairing an oxidized residue can reset a signaling switch.","description":"Msra-null mice had greater CaMKII oxidation, myocardial apoptosis and post-infarction dysfunction; 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unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Msra-knockout mice with biochemical support.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"MSRA and selenium-dependent MSRB1 differ in substrate stereochemistry; they are not interchangeable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Repairing an oxidized residue can reset a signaling switch.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18455987/ · DOI 10.1016/j.cell.2008.02.048","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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