{"id":"f5d64507-b8dc-5175-863e-214da883df08","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-a-rat-pk","predicate":"delivers","statement":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine A gave 24.39% estimated absolute bioavailability; erinacine A was detected in brain at 1 hour and peaked at 8 hours.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a6beea48-e804-5086-b679-0b800063ba97","mechanism_event_label":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine A gave 24.39% estimated absolute bioavailability; erinacine A was detected in brain at 1 hour and peaked at 8 hours.","subject":{"id":"a0135c6c-200d-5795-b4e0-24dac53193db","slug":"erinacine-a-enriched-mycelial-extract","display_name":"Erinacine-A-containing Hericium mycelial extract","entity_type_key":"botanical"},"object":{"id":"0665d81c-c5d4-518b-82dd-a8338bb9ebc7","slug":"erinacine-a","display_name":"Erinacine A","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a6beea48-e804-5086-b679-0b800063ba97","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-a-rat-pk-event","event_type":"observed_relationship","label":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine A gave 24.39% estimated absolute bioavailability; erinacine A was detected in brain at 1 hour and peaked at 8 hours.","description":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine A gave 24.39% estimated absolute bioavailability; erinacine A was detected in brain at 1 hour and peaked at 8 hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a0135c6c-200d-5795-b4e0-24dac53193db","slug":"erinacine-a-enriched-mycelial-extract","display_name":"Erinacine-A-containing Hericium mycelial extract","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0665d81c-c5d4-518b-82dd-a8338bb9ebc7","slug":"erinacine-a","display_name":"Erinacine A","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Oral extract equivalent to 50 mg/kg erinacine A; IV isolated erinacine A 5 mg/kg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Up to the distribution/elimination interval","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sprague-Dawley rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rat brain detection does not establish human blood-brain-barrier penetration; oral dosing used an extract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hericenones-erinacines","display_name":"Hericenones and erinacines","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Sprague-Dawley rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine A gave 24.39% estimated absolute bioavailability; erinacine A was detected in brain at 1 hour and peaked at 8 hours.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Preclinical Bioavailability, Tissue Distribution, and Protein Binding Studies of Erinacine A, a Bioactive Compound from Hericium erinaceus Mycelia Using Validated LC-MS/MS Method. (2021). https://pubmed.ncbi.nlm.nih.gov/34361662/ DOI: 10.3390/molecules26154510","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral and intravenous","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"LC-MS/MS bioavailability and tissue distribution","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"632ae0db-f8b4-513e-9b63-ded834c3ca2e","evidence_kind":"source_excerpt","locator":"Lines 110-119","start_line":110,"end_line":119,"excerpt":"## hericenones-erinacines-erinacine-a-rat-pk\nIn rats, oral mycelial extract equivalent to 50 mg/kg erinacine A gave 24.39% estimated absolute bioavailability; erinacine A was detected in brain at 1 hour and peaked at 8 hours.\nModel/species: Sprague-Dawley rats\nTissue/system: LC-MS/MS bioavailability and tissue distribution\nExposure: Oral extract equivalent to 50 mg/kg erinacine A; IV isolated erinacine A 5 mg/kg\nRoute: Oral and intravenous\nDuration: Up to the distribution/elimination interval\nLimits: Rat brain detection does not establish human blood-brain-barrier penetration; oral dosing used an extract.\nPrimary reference: Preclinical Bioavailability, Tissue Distribution, and Protein Binding Studies of Erinacine A, a Bioactive Compound from Hericium erinaceus Mycelia Using Validated LC-MS/MS Method. (2021). https://pubmed.ncbi.nlm.nih.gov/34361662/ DOI: 10.3390/molecules26154510\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Sprague-Dawley rats","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"aa7c09fd-ab4a-51ff-b463-d35547dc41ba","stable_key":"import-d39c4b36-9a88-5f52-8e6b-93a248dc4bfc","title":"Hericenones & Erinacines: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"f1ff2966f222f5c463e8e509ec1b1642a0053cd38f121f3847cdd21855c46e85","revision_id":"d00076e0-da87-5100-92ed-0525190b25a1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}