{"id":"f5cb2dbc-ca58-5068-96fb-8f66f71ec2cf","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-reg-tocopherol-antiperoxidation-persistence","predicate":"prolongs-tocopherol-dependent-inhibition","statement":"The inhibitory effect of alpha-tocopherol on liposome lipid peroxidation persisted while aqueous ascorbic acid remained available, consistent with continued tocopherol-radical recycling.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"977d7030-2f1a-59d5-ba33-a7792e45423a","mechanism_event_label":"Vitamin C prolonged vitamin E’s protection against oxidation in the liposome experiment.","subject":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"977d7030-2f1a-59d5-ba33-a7792e45423a","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-reg-tocopherol-antiperoxidation-persistence-event","event_type":"biochemical_relationship","label":"Vitamin C prolonged vitamin E’s protection against oxidation in the liposome experiment.","description":"The inhibitory effect of alpha-tocopherol on liposome lipid peroxidation persisted while aqueous ascorbic acid remained available, consistent with continued tocopherol-radical recycling.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"role":"nutrient context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"chain-breaking antioxidant","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ec585435-0fdf-5f6f-97d9-6fff230d405e","slug":"alpha-tocopheroxyl-radical","display_name":"Alpha-tocopheroxyl radical","entity_type_key":"chemical_species"},"role":"recycling intermediate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary abstract final result","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Soybean L-alpha-phosphatidylcholine liposomes undergoing Fe(III)-triethylenetetramine-initiated peroxidation; EPR, optical and polarographic measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Aqueous ascorbic acid described as physiological concentration in abstract (exact dose unavailable); bilayer alpha-tocopheroxyl radical detected at 10^-8–10^-7 M.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This persistence endpoint is separate from the radical-reduction reaction and does not establish a supplementation effect in people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Glycine max lipid preparation; cell-free","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Vitamin C prolonged vitamin E’s protection against oxidation in the liposome experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-reg-scarpa] Formation of alpha-tocopherol radical and recycling of alpha-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes. An electron paramagnetic resonance study. (1984). https://pubmed.ncbi.nlm.nih.gov/6089911/ DOI: 10.1016/0304-4165(84)90070-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Artificial liposomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c40fb724-35f5-5698-92af-f72d33a2cede","evidence_kind":"source_excerpt","locator":"Lines 1215-1227","start_line":1215,"end_line":1227,"excerpt":"### c-reg-tocopherol-antiperoxidation-persistence\nThe inhibitory effect of alpha-tocopherol on liposome lipid peroxidation persisted while aqueous ascorbic acid remained available, consistent with continued tocopherol-radical recycling.\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Vitamin C prolonged vitamin E’s protection against oxidation in the liposome experiment.\norganism: Glycine max lipid preparation; cell-free\ntissue_or_cell_type: Artificial liposomes\nexperimental_model: Soybean L-alpha-phosphatidylcholine liposomes undergoing Fe(III)-triethylenetetramine-initiated peroxidation; EPR, optical and polarographic measurements\nlimitations: This persistence endpoint is separate from the radical-reduction reaction and does not establish a supplementation effect in people.\nexposure: Aqueous ascorbic acid described as physiological concentration in abstract (exact dose unavailable); bilayer alpha-tocopheroxyl radical detected at 10^-8–10^-7 M.\ncross_nutrient: true\nevidence_location: Primary abstract final result\n[c-reg-scarpa] Formation of alpha-tocopherol radical and recycling of alpha-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes. An electron paramagnetic resonance study. (1984). https://pubmed.ncbi.nlm.nih.gov/6089911/ DOI: 10.1016/0304-4165(84)90070-9","model_system":"Soybean L-alpha-phosphatidylcholine liposomes undergoing Fe(III)-triethylenetetramine-initiated peroxidation; EPR, optical and polarographic measurements","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-reg-scarpa] Formation of alpha-tocopherol radical and recycling of alpha-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes. An electron paramagnetic resonance study. (1984). https://pubmed.ncbi.nlm.nih.gov/6089911/ DOI: 10.1016/0304-4165(84)90070-9","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}