{"id":"f547ca45-c6ba-59ed-b06c-411f502f3d5a","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-formulation-ratio","predicate":"increases_more_in_solution","statement":"Solution versus capsules produced a higher plasma phenylalanine-to-other-LNAA ratio, 0.36 versus 0.23.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"105a82a9-e35f-5862-8299-9984ef1d2414","mechanism_event_label":"Transport competition depends partly on the mixture reaching blood.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"a758fb85-4634-5613-965e-ae06134fc1db","slug":"human-plasma-phe-lnaa-ratio","display_name":"Human plasma phenylalanine/large-neutral-amino-acid ratio","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"105a82a9-e35f-5862-8299-9984ef1d2414","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-formulation-ratio-event","event_type":"observed_relationship","label":"Transport competition depends partly on the mixture reaching blood.","description":"Solution versus capsules produced a higher plasma phenylalanine-to-other-LNAA ratio, 0.36 versus 0.23.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a758fb85-4634-5613-965e-ae06134fc1db","slug":"human-plasma-phe-lnaa-ratio","display_name":"Human plasma phenylalanine/large-neutral-amino-acid ratio","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same ten-person 3 g comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The ratio is not a measured change in brain serotonin or dopamine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Transport competition depends partly on the mixture reaching blood.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Plasma amino acid concentrations in normal adults administered aspartame in capsules or solution: lack of bioequivalence. · 1987 · https://pubmed.ncbi.nlm.nih.gov/3574137/ · DOI 10.1016/0026-0495(87)90052-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"bde3df70-aaea-5f65-8c01-2dfcdce3d381","evidence_kind":"source_excerpt","locator":"Lines 90-96","start_line":90,"end_line":96,"excerpt":"## aspartame-formulation-ratio\nTransport competition depends partly on the mixture reaching blood.\nSolution versus capsules produced a higher plasma phenylalanine-to-other-LNAA ratio, 0.36 versus 0.23.\nModel: Same ten-person 3 g comparison.\nLimitations: The ratio is not a measured change in brain serotonin or dopamine.\nEvidence access: Primary abstract\nPlasma amino acid concentrations in normal adults administered aspartame in capsules or solution: lack of bioequivalence. · 1987 · https://pubmed.ncbi.nlm.nih.gov/3574137/ · DOI 10.1016/0026-0495(87)90052-7","model_system":"Same ten-person 3 g comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"21cfc6808062c6ea1fb5d34128bcd005d31f0f6c0d63484794238db77d32ae97","revision_id":"1255dda8-df99-5d4b-a65b-4144c47d7d9b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}