{"id":"f518c0ec-6a21-50a9-b92d-5c36a1e77f70","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:lariciresinol-arrests-hepatoma-cells-in-s-phase","predicate":"increases","statement":"Lariciresinol inhibited proliferation of hepatoma cells and induced cell cycle arrest in S phase.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"28606c2d-abff-53c9-b2c5-9aa6aea07ce5","mechanism_event_label":"Lariciresinol inhibited proliferation of hepatoma cells and induced cell cycle arrest in S phase.","subject":{"id":"4fcf5405-bafb-54bf-89b8-2fc11e0d9822","slug":"lariciresinol","display_name":"Lariciresinol, enantiomer unresolved","entity_type_key":"small_molecule"},"object":{"id":"0c9f2262-78e7-5815-8406-55eb4bc54c96","slug":"hepg2-s-phase-arrest","display_name":"S-phase arrest in HepG2 hepatoma cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"28606c2d-abff-53c9-b2c5-9aa6aea07ce5","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:lariciresinol-arrests-hepatoma-cells-in-s-phase-event","event_type":"observed_relationship","label":"Lariciresinol inhibited proliferation of hepatoma cells and induced cell cycle arrest in S phase.","description":"Lariciresinol inhibited proliferation of hepatoma cells and induced cell cycle arrest in S phase.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4fcf5405-bafb-54bf-89b8-2fc11e0d9822","slug":"lariciresinol","display_name":"Lariciresinol, enantiomer unresolved","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0c9f2262-78e7-5815-8406-55eb4bc54c96","slug":"hepg2-s-phase-arrest","display_name":"S-phase arrest in HepG2 hepatoma cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human HepG2 hepatoma cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lariciresinol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No cyclin or cyclin-dependent kinase is identified in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human HepG2 hepatoma cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lariciresinol inhibited proliferation of hepatoma cells and induced cell cycle arrest in S phase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Proteomic analysis of apoptosis induction by lariciresinol in human HepG2 cells. (2016). https://pubmed.ncbi.nlm.nih.gov/27417256/ DOI: 10.1016/j.cbi.2016.07.013","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Cell cycle distribution and proliferation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"29561be7-6563-51e4-8f7b-33230d1bd808","evidence_kind":"source_excerpt","locator":"Lines 220-229","start_line":220,"end_line":229,"excerpt":"## lariciresinol-arrests-hepatoma-cells-in-s-phase\nLariciresinol inhibited proliferation of hepatoma cells and induced cell cycle arrest in S phase.\nModel/species: Human HepG2 hepatoma cells\nTissue/system: Cell cycle distribution and proliferation\nExposure: Lariciresinol\nRoute: In vitro\nDuration: Not stated here\nLimits: No cyclin or cyclin-dependent kinase is identified in the abstract.\nPrimary reference: Proteomic analysis of apoptosis induction by lariciresinol in human HepG2 cells. (2016). https://pubmed.ncbi.nlm.nih.gov/27417256/ DOI: 10.1016/j.cbi.2016.07.013\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"48c58761-0291-5bad-a926-75e904b2d802","stable_key":"import-96d9034a-2550-5f3c-b767-1767c982533c","title":"Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. 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