{"id":"f51381af-a0c6-572d-95a1-d8a78d8a404d","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-metabolite-dihydro-ionone","predicate":"metabolized_to","statement":"Astaxanthin metabolism yielded 7,8-Dihydro-3-hydroxy-4-oxo-beta-ionone in the human hepatocyte investigation; the study also detected the four reported metabolites in plasma after oral exposure.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"83fb666c-a0d6-535c-837f-66db03916fec","mechanism_event_label":"Metabolism produced a separately identifiable smaller molecule.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"e2d7f4b9-a41e-58cd-a821-d8f493b7f32f","slug":"7-8-dihydro-3-hydroxy-4-oxo-beta-ionone","display_name":"7,8-Dihydro-3-hydroxy-4-oxo-beta-ionone","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"83fb666c-a0d6-535c-837f-66db03916fec","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-metabolite-dihydro-ionone-event","event_type":"observed_relationship","label":"Metabolism produced a separately identifiable smaller molecule.","description":"Astaxanthin metabolism yielded 7,8-Dihydro-3-hydroxy-4-oxo-beta-ionone in the human hepatocyte investigation; the study also detected the four reported metabolites in plasma after oral exposure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e2d7f4b9-a41e-58cd-a821-d8f493b7f32f","slug":"7-8-dihydro-3-hydroxy-4-oxo-beta-ionone","display_name":"7,8-Dihydro-3-hydroxy-4-oxo-beta-ionone","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary human hepatocytes; plasma examination in two volunteers after 100 mg.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The cleavage enzyme was not identified; two high-dose exposures do not establish routine tissue concentrations or biological activity of this metabolite.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Metabolism produced a separately identifiable smaller molecule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11876499/ · DOI 10.1007/s00204-001-0287-5","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"900c77b7-bfb9-5a9d-861c-ea0c856d80a5","evidence_kind":"source_excerpt","locator":"Lines 126-132","start_line":126,"end_line":132,"excerpt":"## astaxanthin-metabolite-dihydro-ionone\nMetabolism produced a separately identifiable smaller molecule.\nAstaxanthin metabolism yielded 7,8-Dihydro-3-hydroxy-4-oxo-beta-ionone in the human hepatocyte investigation; the study also detected the four reported metabolites in plasma after oral exposure.\nModel: Primary human hepatocytes; plasma examination in two volunteers after 100 mg.\nLimitations: The cleavage enzyme was not identified; two high-dose exposures do not establish routine tissue concentrations or biological activity of this metabolite.\nEvidence access: Primary abstract\nMetabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11876499/ · DOI 10.1007/s00204-001-0287-5","model_system":"Primary human hepatocytes; plasma examination in two volunteers after 100 mg.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}