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zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7041ada7ee2ce923645d1103db3a3dccc3febcf138c5095e24aa96cdbc04e9e3\", \"start_char\": 0, \"end_char\": 1309, \"text_sha256\": \"7041ada7ee2ce923645d1103db3a3dccc3febcf138c5095e24aa96cdbc04e9e3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Tissue glutathione and covalent binding of tritiated metabolites in CD-1 mice and Sprague-Dawley rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Intraperitoneal acetaminophen, with and without prior 3-methylcholanthrene induction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Compares two organs and two species in the same design. The authors note the covalent binding measurement is extremely sensitive to trace radiochemical impurity, which is an honest caution about the method.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Paracetamol research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from the metabolites NAPQI and AM404.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetaminophen","display_name":"Paracetamol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Mouse and rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The drug empties the cell of its protective thiol and then sticks to proteins, most of all in mouse liver.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[apap-p660552] Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione. 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The authors note the covalent binding measurement is extremely sensitive to trace radiochemical impurity, which is an honest caution about the method.\nexposure: Intraperitoneal acetaminophen, with and without prior 3-methylcholanthrene induction\nevidence_span: {\"source_cache\": \"artifacts/paracetamol-research/660552.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7041ada7ee2ce923645d1103db3a3dccc3febcf138c5095e24aa96cdbc04e9e3\", \"start_char\": 0, \"end_char\": 1309, \"text_sha256\": \"7041ada7ee2ce923645d1103db3a3dccc3febcf138c5095e24aa96cdbc04e9e3\"}\n[apap-p660552] Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione. 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