{"id":"f4cc0d6a-72b9-5b12-976e-0ddb424c8ffc","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-mk7-thrombin","predicate":"increases_during_vka_treatment","statement":"MK-7 at 10 and 20 micrograms/day increased endogenous thrombin potential by approximately 20% and 30%, respectively; ucOC and dp-ucMGP did not change.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"851ffa64-8ffb-527f-ac4b-a42daab0538e","mechanism_event_label":"A clotting response appeared without the same response in the other measured proteins.","subject":{"id":"a3ff2a7b-69f3-5098-8fac-fb8d7668397b","slug":"menaquinone-7","display_name":"Menaquinone-7 / MK-7","entity_type_key":"small_molecule"},"object":{"id":"57d610ed-c41d-5cbe-ab26-ad486ebd5a85","slug":"endogenous-thrombin-potential","display_name":"Endogenous thrombin generation potential","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"851ffa64-8ffb-527f-ac4b-a42daab0538e","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-mk7-thrombin-event","event_type":"observed_intervention","label":"A clotting response appeared without the same response in the other measured proteins.","description":"MK-7 at 10 and 20 micrograms/day increased endogenous thrombin potential by approximately 20% and 30%, respectively; ucOC and dp-ucMGP did not change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a3ff2a7b-69f3-5098-8fac-fb8d7668397b","slug":"menaquinone-7","display_name":"Menaquinone-7 / MK-7","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57d610ed-c41d-5cbe-ab26-ad486ebd5a85","slug":"endogenous-thrombin-potential","display_name":"Endogenous thrombin generation potential","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/k2-research/23530987.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af\", \"start_char\": 0, \"end_char\": 1740, \"text_sha256\": \"95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sequential dose-response intervention during anticoagulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Acenocoumarol followed by MK-7 10, 20 and 45 micrograms/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small pharmacological study; no dose here is a recommended safe self-adjustment. Drug was acenocoumarol, not warfarin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"18 healthy adults; 15 attained target INR","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A clotting response appeared without the same response in the other measured proteins.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p23530987] Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/23530987/ DOI: 10.1111/jth.12203","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Coagulation, osteocalcin and MGP markers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"ebb6bc8d-1755-5dc3-95cd-e2f6158c70fd","evidence_kind":"source_excerpt","locator":"Lines 1059-1070","start_line":1059,"end_line":1070,"excerpt":"### k2-mk7-thrombin\nMK-7 at 10 and 20 micrograms/day increased endogenous thrombin potential by approximately 20% and 30%, respectively; ucOC and dp-ucMGP did not change.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A clotting response appeared without the same response in the other measured proteins.\norganism: 18 healthy adults; 15 attained target INR\ntissue_or_cell_type: Coagulation, osteocalcin and MGP markers\nexperimental_model: Sequential dose-response intervention during anticoagulation\nlimitations: Small pharmacological study; no dose here is a recommended safe self-adjustment. Drug was acenocoumarol, not warfarin.\nexposure: Acenocoumarol followed by MK-7 10, 20 and 45 micrograms/day\nevidence_span: {\"source_cache\": \"artifacts/k2-research/23530987.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af\", \"start_char\": 0, \"end_char\": 1740, \"text_sha256\": \"95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af\"}\n[k2-p23530987] Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/23530987/ DOI: 10.1111/jth.12203","model_system":"Sequential dose-response intervention during anticoagulation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k2-p23530987] Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/23530987/ DOI: 10.1111/jth.12203","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dfeae572-af3d-5042-a10e-e67596f9ab28","stable_key":"import-4fef8d72-f107-5eb5-b2fb-483ca85465e0","title":"Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"dc31aff21110d09b025c177e03b4c5ca8349d52bf5f962285fdbfcf660c0e4f6","revision_id":"850887db-34f6-55aa-9d3e-b8fd3a4a5de3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}