{"id":"f4c2c2ec-0b36-5b39-be70-38dab927590c","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-saliva-hoi","predicate":"increases","statement":"Salivary hypoiodous acid increased after contrast exposure and its change correlated with iodine load.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e715ec4d-ad47-5433-bb1e-1e175f57084e","mechanism_event_label":"The saliva contained more of an oxidized iodine species.","subject":{"id":"46466f17-36bd-5b59-a646-a91814566209","slug":"iodinated-contrast-media","display_name":"Iodinated contrast media, study mixture","entity_type_key":"chemical_species"},"object":{"id":"9114dba2-4124-5df6-b1b7-3eaaab2ef9b9","slug":"salivary-hypoiodous-acid-concentration","display_name":"Salivary hypoiodous acid concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e715ec4d-ad47-5433-bb1e-1e175f57084e","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-saliva-hoi-event","event_type":"observed_relationship","label":"The saliva contained more of an oxidized iodine species.","description":"Salivary hypoiodous acid increased after contrast exposure and its change correlated with iodine load.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"46466f17-36bd-5b59-a646-a91814566209","slug":"iodinated-contrast-media","display_name":"Iodinated contrast media, study mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9114dba2-4124-5df6-b1b7-3eaaab2ef9b9","slug":"salivary-hypoiodous-acid-concentration","display_name":"Salivary hypoiodous acid concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"55b8f92b-59c6-5e1d-8262-d64f4308bbd1","slug":"hypoiodous-acid","display_name":"Hypoiodous acid (HOI)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3d671567-4fb6-5b5f-a328-156987d5b396","slug":"lactoperoxidase-family","display_name":"Lactoperoxidase enzyme family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Contrast exposure is not oral KI; observational chemistry endpoints do not establish infection prevention or a safe effective supplement dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The saliva contained more of an oxidized iodine species.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Excess iodine exposure acutely increases salivary iodide and antimicrobial hypoiodous acid concentrations in humans. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36463312/ · DOI 10.1038/s41598-022-23803-8","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"280a045a-7d1b-57aa-a1f6-dd1c3adc96cc","evidence_kind":"source_excerpt","locator":"Lines 168-174","start_line":168,"end_line":174,"excerpt":"## ki-saliva-hoi\nThe saliva contained more of an oxidized iodine species.\nSalivary hypoiodous acid increased after contrast exposure and its change correlated with iodine load.\nModel: Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast.\nLimitations: Contrast exposure is not oral KI; observational chemistry endpoints do not establish infection prevention or a safe effective supplement dose.\nEvidence location: Primary abstract\nExcess iodine exposure acutely increases salivary iodide and antimicrobial hypoiodous acid concentrations in humans. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36463312/ · DOI 10.1038/s41598-022-23803-8","model_system":"Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. 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