{"id":"f4b42706-7906-5ccb-bf72-05a4ecf58235","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-lysosome-leucine","predicate":"mediates","statement":"SLC38A9 mediated arginine-regulated export of essential amino acids, including leucine, from lysosomes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"93956ace-5c37-5d35-bb12-a7c7139a487e","mechanism_event_label":"Arginine sensing helps make another amino acid available to the cell.","subject":{"id":"571e470b-c75e-5ef0-aadd-975a1d9d9da5","slug":"slc38a9","display_name":"Human lysosomal amino acid transporter SLC38A9","entity_type_key":"protein"},"object":{"id":"8fbac48a-4308-52ee-8436-9373222df0f9","slug":"lysosomal-leucine-efflux","display_name":"Leucine export from lysosomes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"93956ace-5c37-5d35-bb12-a7c7139a487e","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-lysosome-leucine-event","event_type":"observed_relationship","label":"Arginine sensing helps make another amino acid available to the cell.","description":"SLC38A9 mediated arginine-regulated export of essential amino acids, including leucine, from lysosomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"571e470b-c75e-5ef0-aadd-975a1d9d9da5","slug":"slc38a9","display_name":"Human lysosomal amino acid transporter SLC38A9","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8fbac48a-4308-52ee-8436-9373222df0f9","slug":"lysosomal-leucine-efflux","display_name":"Leucine export from lysosomes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f707c753-cc8c-5f06-90be-bb3d73c60a18","slug":"leucine","display_name":"L-Leucine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Lysosomal transport and mammalian-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is a compartment-specific mechanism, not a demonstrated arginine–leucine supplement synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Arginine sensing helps make another amino acid available to the cell.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29053970/ · DOI 10.1016/j.cell.2017.09.046","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0661c3e5-648f-54fd-acc9-c532e56b18ce","evidence_kind":"source_excerpt","locator":"Lines 206-212","start_line":206,"end_line":212,"excerpt":"## arg-lysosome-leucine\nArginine sensing helps make another amino acid available to the cell.\nSLC38A9 mediated arginine-regulated export of essential amino acids, including leucine, from lysosomes.\nModel: Lysosomal transport and mammalian-cell experiments.\nLimitations: This is a compartment-specific mechanism, not a demonstrated arginine–leucine supplement synergy.\nEvidence access: Primary abstract\nmTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29053970/ · DOI 10.1016/j.cell.2017.09.046","model_system":"Lysosomal transport and mammalian-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}