{"id":"f4914bbf-0d36-57e8-9d85-fcad09d85815","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:mitochondrial-lysine-transport","predicate":"transports","statement":"Reconstituted human SLC25A29 transports lysine by uniport and exchange, supporting lysine entry into the mitochondrial matrix.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2226710a-5fc6-5ed0-adf5-11a57d6ed091","mechanism_event_label":"SLC25A29 gives lysine access to mitochondrial metabolism.","subject":{"id":"19cdaf69-6272-5d24-aecb-4bfbbc0378d4","slug":"slc25a29","display_name":"SLC25A29","entity_type_key":"protein"},"object":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"2226710a-5fc6-5ed0-adf5-11a57d6ed091","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:mitochondrial-lysine-transport-event","event_type":"biochemical_relationship","label":"SLC25A29 gives lysine access to mitochondrial metabolism.","description":"Reconstituted human SLC25A29 transports lysine by uniport and exchange, supporting lysine entry into the mitochondrial matrix.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"19cdaf69-6272-5d24-aecb-4bfbbc0378d4","slug":"slc25a29","display_name":"SLC25A29","entity_type_key":"protein"},"role":"transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f2cf4a9-0168-5691-8b00-1676e5a477e1","slug":"mitochondrial-matrix","display_name":"Mitochondrial matrix","entity_type_key":"organelle"},"role":"destination","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Purified recombinant carrier reconstituted in liposomes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Physiological import role is inferred from transport properties and localization; not a carnitine transporter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"SLC25A29 gives lysine access to mitochondrial metabolism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[porcelli2014] The Human Gene SLC25A29, of Solute Carrier Family 25, Encodes a Mitochondrial Transporter of Basic Amino Acids (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4036346/ DOI: 10.1074/jbc.M114.547448","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Inner mitochondrial membrane","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Uniport and exchange supporting lysine entry into the matrix.","entity":null},{"dimension":"transport_pool","value_text":"the mitochondrial matrix","comparator":null,"unit":null,"notes":"Uniport and exchange supporting lysine entry into the matrix.","entity":null}],"evidence":[{"id":"6fd78b9d-8fb5-5b58-b39c-0c7ca531789f","evidence_kind":"source_excerpt","locator":"Lines 44-52","start_line":44,"end_line":52,"excerpt":"### mitochondrial-lysine-transport\nReconstituted human SLC25A29 transports lysine by uniport and exchange, supporting lysine entry into the mitochondrial matrix.\nPlain language: SLC25A29 gives lysine access to mitochondrial metabolism.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Inner mitochondrial membrane\nexperimental_model: Purified recombinant carrier reconstituted in liposomes\nlimitations: Physiological import role is inferred from transport properties and localization; not a carnitine transporter.\n[porcelli2014] The Human Gene SLC25A29, of Solute Carrier Family 25, Encodes a Mitochondrial Transporter of Basic Amino Acids (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4036346/ DOI: 10.1074/jbc.M114.547448","model_system":"Purified recombinant carrier reconstituted in liposomes","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [porcelli2014] The Human Gene SLC25A29, of Solute Carrier Family 25, Encodes a Mitochondrial Transporter of Basic Amino Acids (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4036346/ DOI: 10.1074/jbc.M114.547448","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}