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(2007). https://pubmed.ncbi.nlm.nih.gov/17456783/ DOI: 10.1096/fj.07-8227com","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Primary hepatocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"666c192a-2a97-5c20-91b5-3f87709bfab4","evidence_kind":"source_excerpt","locator":"Lines 841-852","start_line":841,"end_line":852,"excerpt":"### choline-estrogen-pemt-activity\nThe increased PEMT message was accompanied by higher protein expression and enzyme activity in the hepatocyte study.\nCondition category: normal\nnutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The response extended beyond an RNA measurement.\norganism: Human primary hepatocytes\ntissue_or_cell_type: Primary hepatocytes\nexperimental_model: Primary-hepatocyte estrogen exposure\nlimitations: Culture regulation supports a mechanism but does not set requirements for every person or justify hormone treatment.\nexposure: 17-beta-estradiol treatment for 24 hours\nevidence_span: {\"source_cache\": \"artifacts/choline-research/17456783.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d3585209a8c4db7cfe8b93aa2587fdd570f5e5c42bd3ea8f6195feb60b23b9da\", \"start_char\": 0, \"end_char\": 1399, \"text_sha256\": \"d3585209a8c4db7cfe8b93aa2587fdd570f5e5c42bd3ea8f6195feb60b23b9da\"}\n[choline-p17456783] Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. 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