{"id":"f457cc7c-7057-5b97-a90c-6cec993c4517","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-increases-parathyroid-casr-expression","predicate":"increases-expression-of","statement":"At 1.0 mM Ca, six-hour exposure to 2.0 versus 0.5 mM Mg increased CaSR mRNA and protein in intact rat glands.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"3d0df414-449f-59ea-8ade-5b577406f096","mechanism_event_label":"Mg exposure can change the amount of the calcium-sensing receptor, adding a slower response to immediate ion sensing.","subject":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"object":{"id":"1c0d5c58-d358-5501-9bdf-8999bcf79fd4","slug":"casr","display_name":"Calcium-sensing receptor / CaSR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"3d0df414-449f-59ea-8ade-5b577406f096","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-increases-parathyroid-casr-expression-event","event_type":"biochemical_relationship","label":"Mg exposure can change the amount of the calcium-sensing receptor, adding a slower response to immediate ion sensing.","description":"At 1.0 mM Ca, six-hour exposure to 2.0 versus 0.5 mM Mg increased CaSR mRNA and protein in intact rat glands.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"fixed medium condition","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d725020b-bacc-5e90-b370-cda246025c91","slug":"vdr","display_name":"Vitamin D receptor / VDR","entity_type_key":"protein"},"role":"parallel measured receptor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6aa2a908-0a89-5ac7-91ca-c3a41fc292e3","slug":"fgfr1","display_name":"Fibroblast growth factor receptor 1 / FGFR1","entity_type_key":"protein"},"role":"parallel measured receptor","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f211e124-c0e0-56f9-9602-26419a3bb393","slug":"klotho","display_name":"Alpha-Klotho / KL","entity_type_key":"protein"},"role":"parallel measured coreceptor","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"1c0d5c58-d358-5501-9bdf-8999bcf79fd4","slug":"casr","display_name":"Calcium-sensing receptor / CaSR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"magnesium -> calcium sensing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six-hour ex-vivo gland incubation with receptor expression assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Receptor abundance alone does not prove altered clinical calcium balance; VDR, FGFR1 and Klotho also rose in this experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Mg exposure can change the amount of the calcium-sensing receptor, adding a slower response to immediate ion sensing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[rodriguez-ortiz-2014-pth-context] Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration (2014). https://pubmed.ncbi.nlm.nih.gov/24103811/ DOI: 10.1093/ndt/gft400","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Parathyroid gland","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5d5f71f4-0957-5504-9e8c-83c022d3e656","evidence_kind":"source_excerpt","locator":"Lines 289-299","start_line":289,"end_line":299,"excerpt":"### mg-increases-parathyroid-casr-expression\nAt 1.0 mM Ca, six-hour exposure to 2.0 versus 0.5 mM Mg increased CaSR mRNA and protein in intact rat glands.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Mg exposure can change the amount of the calcium-sensing receptor, adding a slower response to immediate ion sensing.\norganism: Rattus norvegicus\ntissue_or_cell_type: Parathyroid gland\nexperimental_model: Six-hour ex-vivo gland incubation with receptor expression assays\nlimitations: Receptor abundance alone does not prove altered clinical calcium balance; VDR, FGFR1 and Klotho also rose in this experiment.\ncross_nutrient: magnesium -> calcium sensing\n[rodriguez-ortiz-2014-pth-context] Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration (2014). https://pubmed.ncbi.nlm.nih.gov/24103811/ DOI: 10.1093/ndt/gft400","model_system":"Six-hour ex-vivo gland incubation with receptor expression assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [rodriguez-ortiz-2014-pth-context] Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration (2014). https://pubmed.ncbi.nlm.nih.gov/24103811/ DOI: 10.1093/ndt/gft400","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}