{"id":"f41ac480-2da5-584d-8967-18ef07b7295e","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-endotoxin-liver","predicate":"associated_with","statement":"Endotoxaemia accompanied the permeability defect and differed across stages of alcohol-induced liver disease.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e37779dc-6a4a-52a2-ab51-2fbd91112940","mechanism_event_label":"The leak and the liver damage travel together.","subject":{"id":"517ec73b-2632-50a0-ad56-aa98869efe63","slug":"plasma-endotoxin","display_name":"Circulating endotoxin concentration","entity_type_key":"cellular_process"},"object":{"id":"b2dd390a-349b-581f-8224-9da1206e4e2a","slug":"alcoholic-liver-injury","display_name":"Alcoholic liver injury","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e37779dc-6a4a-52a2-ab51-2fbd91112940","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-endotoxin-liver-event","event_type":"observed_intervention","label":"The leak and the liver damage travel together.","description":"Endotoxaemia accompanied the permeability defect and differed across stages of alcohol-induced liver disease.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3f792f3c-3129-5995-8341-2295c5ea5b27","slug":"tlr4","display_name":"Human toll-like receptor 4 / TLR4","entity_type_key":"protein"},"role":"candidate_receptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"928342a9-65b4-5370-95e8-9736af7044c4","slug":"cd14","display_name":"Human CD14","entity_type_key":"protein"},"role":"candidate_coreceptor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"517ec73b-2632-50a0-ad56-aa98869efe63","slug":"plasma-endotoxin","display_name":"Circulating endotoxin concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b2dd390a-349b-581f-8224-9da1206e4e2a","slug":"alcoholic-liver-injury","display_name":"Alcoholic liver injury","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/10845660.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0342f8e351dde29e075eaf2d1920f26d1e8ef9d9a704947dc6c08f6f5fde846d\", \"start_char\": 0, \"end_char\": 1618, \"text_sha256\": \"0342f8e351dde29e075eaf2d1920f26d1e8ef9d9a704947dc6c08f6f5fde846d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Intestinal permeability and endotoxin measurement across stages of alcohol-induced liver disease","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chronic alcohol abuse, staged by liver disease severity","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Human observational staging. It shows permeability tracks disease stage; it cannot establish which came first.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The leak and the liver damage travel together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p10845660] Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. 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It shows permeability tracks disease stage; it cannot establish which came first.\nexposure: Chronic alcohol abuse, staged by liver disease severity\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/10845660.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0342f8e351dde29e075eaf2d1920f26d1e8ef9d9a704947dc6c08f6f5fde846d\", \"start_char\": 0, \"end_char\": 1618, \"text_sha256\": \"0342f8e351dde29e075eaf2d1920f26d1e8ef9d9a704947dc6c08f6f5fde846d\"}\n[alcohol-p10845660] Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. 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