{"id":"f3fba6a3-180f-537d-a4b7-ecddbc2e766a","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-duck-mam","predicate":"associated_with_disruption","statement":"Vanadium-exposed duck livers showed wider ER–mitochondrial gaps and altered abundance/association of the IP3R–GRP75–VDAC1 contact complex.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6efc9c45-da8f-5788-8e60-b82a455b222e","mechanism_event_label":"A change at organelle contacts may link calcium handling, metabolism and injury.","subject":{"id":"aa53e24f-9ce4-52cf-80cc-4575c9b10b7a","slug":"ammonium-metavanadate","display_name":"Ammonium metavanadate","entity_type_key":"chemical_species"},"object":{"id":"343168ee-dbef-5ca7-a749-26273f59bf9e","slug":"duck-hepatic-mitochondria-er-contacts","display_name":"Mitochondria–ER contacts in vanadium-exposed duck liver","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6efc9c45-da8f-5788-8e60-b82a455b222e","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-duck-mam-event","event_type":"observed_relationship","label":"A change at organelle contacts may link calcium handling, metabolism and injury.","description":"Vanadium-exposed duck livers showed wider ER–mitochondrial gaps and altered abundance/association of the IP3R–GRP75–VDAC1 contact complex.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"aa53e24f-9ce4-52cf-80cc-4575c9b10b7a","slug":"ammonium-metavanadate","display_name":"Ammonium metavanadate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"343168ee-dbef-5ca7-a749-26273f59bf9e","slug":"duck-hepatic-mitochondria-er-contacts","display_name":"Mitochondria–ER contacts in vanadium-exposed duck liver","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Duck liver ultrastructure and MAM proteomics/co-association measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No genetic or inhibitor rescue establishing this chain was extracted. Human orthologues are not substituted for duck measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A change at organelle contacts may link calcium handling, metabolism and injury.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41362732/ · DOI 10.7150/ijbs.123482","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"01d94067-fab0-56ed-a5df-76da68f43d42","evidence_kind":"source_excerpt","locator":"Lines 366-372","start_line":366,"end_line":372,"excerpt":"## vanadium-duck-mam\nA change at organelle contacts may link calcium handling, metabolism and injury.\nVanadium-exposed duck livers showed wider ER–mitochondrial gaps and altered abundance/association of the IP3R–GRP75–VDAC1 contact complex.\nModel: Duck liver ultrastructure and MAM proteomics/co-association measurements.\nLimitations: No genetic or inhibitor rescue establishing this chain was extracted. Human orthologues are not substituted for duck measurements.\nEvidence access: Primary full text\nDual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41362732/ · DOI 10.7150/ijbs.123482","model_system":"Duck liver ultrastructure and MAM proteomics/co-association measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"d36b30d972e756ca4d19b66f976980e206c65025bd4bbf4c127c17320bd019c2","revision_id":"70d42967-8032-5627-8670-f59841735e89","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}