{"id":"f33355c5-0797-58e8-adbf-0672715843d4","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-mood-disorder-trial","predicate":"associated_with_in_small_trial","statement":"A seven-day 30 mg/kg/day crossover reported more severe symptoms in participants with depression; the study stopped after 13 people completed because of reactions.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6a36b0cd-6320-52d3-a947-3fbd84aba2d2","mechanism_event_label":"An early-stopped study signals a question but cannot define a reliable population effect.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"6d9dfc2f-234b-579b-969c-62633880a104","slug":"human-aspartame-mood-disorder-symptoms","display_name":"Human mood-disorder symptoms in halted aspartame study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6a36b0cd-6320-52d3-a947-3fbd84aba2d2","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-mood-disorder-trial-event","event_type":"observed_relationship","label":"An early-stopped study signals a question but cannot define a reliable population effect.","description":"A seven-day 30 mg/kg/day crossover reported more severe symptoms in participants with depression; the study stopped after 13 people completed because of reactions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6d9dfc2f-234b-579b-969c-62633880a104","slug":"human-aspartame-mood-disorder-symptoms","display_name":"Human mood-disorder symptoms in halted aspartame study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small human psychiatric-history comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Early stopping, small sample and subgroup analysis; no measured neurotransmitter mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An early-stopped study signals a question but cannot define a reliable population effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8373935/ · DOI 10.1016/0006-3223(93)90251-8","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7395ea56-107d-5766-bfce-a93d9b7922db","evidence_kind":"source_excerpt","locator":"Lines 338-344","start_line":338,"end_line":344,"excerpt":"## aspartame-mood-disorder-trial\nAn early-stopped study signals a question but cannot define a reliable population effect.\nA seven-day 30 mg/kg/day crossover reported more severe symptoms in participants with depression; the study stopped after 13 people completed because of reactions.\nModel: Small human psychiatric-history comparison.\nLimitations: Early stopping, small sample and subgroup analysis; no measured neurotransmitter mechanism.\nEvidence access: Primary abstract\nAdverse reactions to aspartame: double-blind challenge in patients from a vulnerable population. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8373935/ · DOI 10.1016/0006-3223(93)90251-8","model_system":"Small human psychiatric-history comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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