{"id":"f2ff2fc5-0fc1-5a51-ada6-7b112762e39a","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-csad-cysteic-acid","predicate":"decarboxylates_to","statement":"Human CSAD also catalyzed L-cysteic-acid decarboxylation to taurine in vitro.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9bade647-47fe-5de2-bcc2-6a8ec4b5bda4","mechanism_event_label":"The same enzyme can use a more oxidized substrate to make taurine directly.","subject":{"id":"a5ef2431-b1fa-57c9-a6ea-c877d4a1e3ec","slug":"csad","display_name":"Human cysteine sulfinic acid decarboxylase / CSAD","entity_type_key":"protein"},"object":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"9bade647-47fe-5de2-bcc2-6a8ec4b5bda4","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-csad-cysteic-acid-event","event_type":"observed_relationship","label":"The same enzyme can use a more oxidized substrate to make taurine directly.","description":"Human CSAD also catalyzed L-cysteic-acid decarboxylation to taurine in vitro.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a5ef2431-b1fa-57c9-a6ea-c877d4a1e3ec","slug":"csad","display_name":"Human cysteine sulfinic acid decarboxylase / CSAD","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f8a0b5f6-19b8-51a4-bb1a-c3b362bf4e4f","slug":"l-cysteic-acid","display_name":"L-Cysteic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text, substrate comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human enzyme; L-cysteic-acid substrate assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This alternative reaction does not quantify its contribution to human whole-body synthesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same enzyme can use a more oxidized substrate to make taurine directly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A Novel, Easy Assay Method for Human Cysteine Sulfinic Acid Decarboxylase. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34068845/ · DOI 10.3390/life11050438","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cec620c5-0908-588b-b660-8032c9f682a3","evidence_kind":"source_excerpt","locator":"Lines 49-55","start_line":49,"end_line":55,"excerpt":"## taurine-csad-cysteic-acid\nThe same enzyme can use a more oxidized substrate to make taurine directly.\nHuman CSAD also catalyzed L-cysteic-acid decarboxylation to taurine in vitro.\nModel: Recombinant human enzyme; L-cysteic-acid substrate assays.\nLimitations: This alternative reaction does not quantify its contribution to human whole-body synthesis.\nEvidence access: Primary full text, substrate comparison\nA Novel, Easy Assay Method for Human Cysteine Sulfinic Acid Decarboxylase. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34068845/ · DOI 10.3390/life11050438","model_system":"Recombinant human enzyme; L-cysteic-acid substrate assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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