{"id":"f2f39a7f-9848-508a-af8e-c1321ef2dbe0","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-bco2-loss","predicate":"knockout_increases","statement":"Bco2 deletion increased hepatic astaxanthin accumulation during eight weeks of 0.04% dietary astaxanthin in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"226b11a0-2cb9-5ea1-a84a-ac555fbd2e4f","mechanism_event_label":"Removing carotenoid-processing machinery changed tissue accumulation.","subject":{"id":"3083b76f-f1d1-5642-953d-4fec0d6a7bcd","slug":"mouse-bco2","display_name":"Mouse beta-carotene oxygenase 2 / Bco2","entity_type_key":"protein"},"object":{"id":"ddfb4fae-caed-5856-9ff3-4bbfc89a88b5","slug":"mouse-hepatic-astaxanthin","display_name":"Mouse hepatic astaxanthin accumulation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"226b11a0-2cb9-5ea1-a84a-ac555fbd2e4f","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-bco2-loss-event","event_type":"observed_relationship","label":"Removing carotenoid-processing machinery changed tissue accumulation.","description":"Bco2 deletion increased hepatic astaxanthin accumulation during eight weeks of 0.04% dietary astaxanthin in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3083b76f-f1d1-5642-953d-4fec0d6a7bcd","slug":"mouse-bco2","display_name":"Mouse beta-carotene oxygenase 2 / Bco2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ddfb4fae-caed-5856-9ff3-4bbfc89a88b5","slug":"mouse-hepatic-astaxanthin","display_name":"Mouse hepatic astaxanthin accumulation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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