{"id":"f2d85b2c-481d-5c8f-8cbc-7b53dfdfcaa7","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-gut-parenteral-rescue","predicate":"restores","statement":"Adding 0.5 g/kg/day intravenous threonine to the 0.1 g/kg/day oral supply maintained most measured outcomes, but colonic goblet-cell and mucin differences remained.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4831817e-2673-55b2-9bbb-055fa34b8af6","mechanism_event_label":"Circulating supply compensated for much, but not every feature, of low luminal supply.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"f3c1bf7a-cdf8-539d-91ab-84b0661439d8","slug":"pig-parenteral-threonine-rescue","display_name":"Pig responses to parenteral threonine during oral deficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4831817e-2673-55b2-9bbb-055fa34b8af6","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-gut-parenteral-rescue-event","event_type":"observed_relationship","label":"Circulating supply compensated for much, but not every feature, of low luminal supply.","description":"Adding 0.5 g/kg/day intravenous threonine to the 0.1 g/kg/day oral supply maintained most measured outcomes, but colonic goblet-cell and mucin differences remained.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f3c1bf7a-cdf8-539d-91ab-84b0661439d8","slug":"pig-parenteral-threonine-rescue","display_name":"Pig responses to parenteral threonine during oral deficiency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Parenteral add-back during otherwise intragastric piglet feeding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is not an oral supplement trial; the same animals contribute several outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Circulating supply compensated for much, but not every feature, of low luminal supply.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Adequate oral threonine is critical for mucin production and gut function in neonatal piglets. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17234895/ · DOI 10.1152/ajpgi.00221.2006","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"99c9781d-d67e-5421-82e6-9663b5bedff8","evidence_kind":"source_excerpt","locator":"Lines 234-240","start_line":234,"end_line":240,"excerpt":"## l-threonine-gut-parenteral-rescue\nCirculating supply compensated for much, but not every feature, of low luminal supply.\nAdding 0.5 g/kg/day intravenous threonine to the 0.1 g/kg/day oral supply maintained most measured outcomes, but colonic goblet-cell and mucin differences remained.\nModel: Parenteral add-back during otherwise intragastric piglet feeding.\nLimitations: This is not an oral supplement trial; the same animals contribute several outcomes.\nEvidence access: Primary abstract\nAdequate oral threonine is critical for mucin production and gut function in neonatal piglets. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17234895/ · DOI 10.1152/ajpgi.00221.2006","model_system":"Parenteral add-back during otherwise intragastric piglet feeding.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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