{"id":"f2c31094-d46c-5af0-8980-1b196b16c8f5","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-organic-acid-export","predicate":"increases","statement":"Giving L-carnitine to three patients with propionic acidemia increased urinary propionylcarnitine, verified by mass spectrometry.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0d19809a-f7b5-563a-86de-755a23d9e0ad","mechanism_event_label":"Acyl-group disposal can consume and export carnitine.","subject":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"object":{"id":"51469c47-12cc-580c-910a-31edca75287e","slug":"human-urinary-propionylcarnitine","display_name":"Human urinary propionylcarnitine excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0d19809a-f7b5-563a-86de-755a23d9e0ad","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-organic-acid-export-event","event_type":"observed_relationship","label":"Acyl-group disposal can consume and export carnitine.","description":"Giving L-carnitine to three patients with propionic acidemia increased urinary propionylcarnitine, verified by mass spectrometry.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"51469c47-12cc-580c-910a-31edca75287e","slug":"human-urinary-propionylcarnitine","display_name":"Human urinary propionylcarnitine excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"69ac0570-94d8-59d8-85ef-7f67cf302d16","slug":"propionyl-coa","display_name":"Propionyl-CoA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a8093e02-6e69-592d-a171-f0821c802e28","slug":"propionylcarnitine","display_name":"Propionylcarnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small human metabolic intervention; three healthy comparison subjects excreted mainly acetylcarnitine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Restoration of mitochondrial free CoA was a proposed mechanism, not directly measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Acyl-group disposal can consume and export carnitine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia. · 1984 · https://pubmed.ncbi.nlm.nih.gov/6725560/ · DOI 10.1172/JCI111387","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c3e6cd71-6601-5bb2-8838-d9a2d461ae90","evidence_kind":"source_excerpt","locator":"Lines 250-256","start_line":250,"end_line":256,"excerpt":"## l-carnitine-organic-acid-export\nAcyl-group disposal can consume and export carnitine.\nGiving L-carnitine to three patients with propionic acidemia increased urinary propionylcarnitine, verified by mass spectrometry.\nModel: Small human metabolic intervention; three healthy comparison subjects excreted mainly acetylcarnitine.\nLimitations: Restoration of mitochondrial free CoA was a proposed mechanism, not directly measured.\nEvidence access: Primary abstract\nL-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia. · 1984 · https://pubmed.ncbi.nlm.nih.gov/6725560/ · DOI 10.1172/JCI111387","model_system":"Small human metabolic intervention; three healthy comparison subjects excreted mainly acetylcarnitine.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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