{"id":"f2a954f9-2aa1-5501-8eca-3bf077794fab","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-tyrrs-nucleus","predicate":"promotes_nuclear_translocation","statement":"Resveratrol promoted endogenous TyrRS nuclear translocation in human HeLa cells, coincident with PARP1 auto-PARylation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"218eed24-42d1-5290-9778-77892f979a34","mechanism_event_label":"An amino-acid enzyme moves into a stress-signaling role.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"1e70f8cb-144f-5c63-b862-0c8670840077","slug":"yars1","display_name":"Human cytosolic tyrosyl-tRNA synthetase / YARS1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"218eed24-42d1-5290-9778-77892f979a34","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-tyrrs-nucleus-event","event_type":"observed_relationship","label":"An amino-acid enzyme moves into a stress-signaling role.","description":"Resveratrol promoted endogenous TyrRS nuclear translocation in human HeLa cells, coincident with PARP1 auto-PARylation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1e70f8cb-144f-5c63-b862-0c8670840077","slug":"yars1","display_name":"Human cytosolic tyrosyl-tRNA synthetase / YARS1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d5ab002d-61f0-502f-951a-00b96f059988","slug":"parp1","display_name":"Human PARP1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"HeLa time-course and purified interaction experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Compartment change is not general inhibition of protein synthesis in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An amino-acid enzyme moves into a stress-signaling role.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25533949/ · DOI 10.1038/nature14028","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b912e378-c5c1-5f64-b422-489421db457a","evidence_kind":"source_excerpt","locator":"Lines 294-300","start_line":294,"end_line":300,"excerpt":"## resveratrol-tyrrs-nucleus\nAn amino-acid enzyme moves into a stress-signaling role.\nResveratrol promoted endogenous TyrRS nuclear translocation in human HeLa cells, coincident with PARP1 auto-PARylation.\nModel: HeLa time-course and purified interaction experiments.\nLimitations: Compartment change is not general inhibition of protein synthesis in humans.\nEvidence access: Primary full text\nA human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25533949/ · DOI 10.1038/nature14028","model_system":"HeLa time-course and purified interaction experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}