{"id":"f296fe30-9f9e-53de-a5c8-be5dac317026","stable_key":"6612c190-1948-5bcf-bbe3-a7f6c50fa3cf:l-proline-hypdh-oxalate","predicate":"supports","statement":"Prodh2 deletion reduced urinary oxalate in mouse hyperoxaluria models; combined Grhpr/Prodh2 deletion prevented kidney calcium-oxalate deposition during a 1% hydroxyproline diet.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a17bdb64-a95c-5429-9d71-cb8e113825c6","mechanism_event_label":"A collagen-derived amino acid can feed an oxalate-producing pathway under specific conditions.","subject":{"id":"c7159d4e-e78a-50fa-b06a-66c3fe3e7691","slug":"mouse-prodh2","display_name":"Mouse hydroxyproline dehydrogenase / Prodh2","entity_type_key":"protein"},"object":{"id":"3d13126a-6b93-5907-ad7a-0be5434d3aae","slug":"mouse-hydroxyproline-oxalate-production","display_name":"Hydroxyproline-derived urinary oxalate in mouse hyperoxaluria models","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a17bdb64-a95c-5429-9d71-cb8e113825c6","stable_key":"6612c190-1948-5bcf-bbe3-a7f6c50fa3cf:l-proline-hypdh-oxalate-event","event_type":"observed_relationship","label":"A collagen-derived amino acid can feed an oxalate-producing pathway under specific conditions.","description":"Prodh2 deletion reduced urinary oxalate in mouse hyperoxaluria models; 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unverified.","entity":null}],"evidence":[{"id":"4fec4576-eb94-5bda-8410-8a705122c770","evidence_kind":"source_excerpt","locator":"Lines 294-300","start_line":294,"end_line":300,"excerpt":"## l-proline-hypdh-oxalate\nA collagen-derived amino acid can feed an oxalate-producing pathway under specific conditions.\nProdh2 deletion reduced urinary oxalate in mouse hyperoxaluria models; combined Grhpr/Prodh2 deletion prevented kidney calcium-oxalate deposition during a 1% hydroxyproline diet.\nModel: Genetic mouse models, including Grhpr knockout and a 1% hydroxyproline diet.\nLimitations: Hydroxyproline loading is not equivalent to free proline intake; human efficacy of pathway inhibition was not established.\nEvidence access: Primary abstract\nThe effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31821850/ · DOI 10.1016/j.bbadis.2019.165633","model_system":"Genetic mouse models, including Grhpr knockout and a 1% hydroxyproline diet.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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