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topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Cofactor support did not make the altered proteins structurally normal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cornelius-2012-etfdh-rescue] Molecular mechanisms of riboflavin responsiveness in patients with ETF-QO variations and multiple acyl-CoA dehydrogenation deficiency (2012). https://pubmed.ncbi.nlm.nih.gov/22611163/ DOI: 10.1093/hmg/dds175","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HEK-293-derived variant ETF-QO assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d0128532-6c0a-5721-aa8f-0d3c5d3ecbfa","evidence_kind":"source_excerpt","locator":"Lines 834-845","start_line":834,"end_line":845,"excerpt":"### b2-met-etfdh-thermal-rescue-limit\nResidual low thermal stability of the studied ETF-QO variants indicated that FAD availability did not fully correct their structural defects.\nCondition category: machinery_impairment\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Cofactor support did not make the altered proteins structurally normal.\norganism: Homo sapiens\ntissue_or_cell_type: HEK-293-derived variant ETF-QO assays\nexperimental_model: Human HEK-293 cells expressing patient-associated ETF-QO variants under varied riboflavin and temperature.\nlimitations: Does not determine clinical outcomes during fever or response of an untested mutation.\nexposure: Riboflavin and temperature variation in cell-expression experiments.\nevidence_spans: [{\"source_bundle\": \"artifacts/riboflavin_metabolism_sources.json\", \"source_key\": \"PMID22611163\", \"locator\": \"metadata.abstractText\", \"paragraph_index\": 0, \"char_start\": 0, \"char_end\": 1899, \"evidence_access\": \"primary-abstract\"}]\n[cornelius-2012-etfdh-rescue] Molecular mechanisms of riboflavin responsiveness in patients with ETF-QO variations and multiple acyl-CoA dehydrogenation deficiency (2012). https://pubmed.ncbi.nlm.nih.gov/22611163/ DOI: 10.1093/hmg/dds175","model_system":"Human HEK-293 cells expressing patient-associated ETF-QO variants under varied riboflavin and temperature.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cornelius-2012-etfdh-rescue] Molecular mechanisms of riboflavin responsiveness in patients with ETF-QO variations and multiple acyl-CoA dehydrogenation deficiency (2012). https://pubmed.ncbi.nlm.nih.gov/22611163/ DOI: 10.1093/hmg/dds175","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f7c9578-82bf-5e2d-b5c4-72a79fb4f6af","stable_key":"import-548ab9d6-3a9b-5bed-879c-17d03813b636","title":"Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"680cb6bc8249877f2410f551807f10d390fdd719014137d7414ba3420e29228d","revision_id":"7a61e299-908d-5372-860b-99ed190f9d7a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}