{"id":"f26f83a1-45d3-52a4-b79b-feb937724b63","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-c-ets","predicate":"activates","statement":"Erinacine C activated ETS-consensus transcription in parallel with, and independently of, neurotrophin induction in astrocytic reporter cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"b29d8870-e945-50bc-9db0-b6713d828bae","mechanism_event_label":"Erinacine C activated ETS-consensus transcription in parallel with, and independently of, neurotrophin induction in astrocytic reporter cells.","subject":{"id":"5f9b1918-609a-536a-80db-b6ccb39688f4","slug":"erinacine-c","display_name":"Erinacine C","entity_type_key":"small_molecule"},"object":{"id":"46890632-b1b1-54e7-a4e9-b037385e6c68","slug":"astrocytic-ets-consensus-transcription","display_name":"ETS-consensus transcription in astrocytic cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b29d8870-e945-50bc-9db0-b6713d828bae","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-c-ets-event","event_type":"observed_relationship","label":"Erinacine C activated ETS-consensus transcription in parallel with, and independently of, neurotrophin induction in astrocytic reporter cells.","description":"Erinacine C activated ETS-consensus transcription in parallel with, and independently of, neurotrophin induction in astrocytic reporter cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5f9b1918-609a-536a-80db-b6ccb39688f4","slug":"erinacine-c","display_name":"Erinacine C","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"46890632-b1b1-54e7-a4e9-b037385e6c68","slug":"astrocytic-ets-consensus-transcription","display_name":"ETS-consensus transcription in astrocytic cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Erinacine C concentration series","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute reporter assay","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Astrocytic cells with transcriptional reporters","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Consensus reporter activity does not identify a single ETS-family protein or a human neural outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hericenones-erinacines","display_name":"Hericenones and erinacines","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Astrocytic cells with transcriptional reporters","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Erinacine C activated ETS-consensus transcription in parallel with, and independently of, neurotrophin induction in astrocytic reporter cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Erinacine C Activates Transcription from a Consensus ETS DNA Binding Site in Astrocytic Cells in Addition to NGF Induction. (2020). https://pubmed.ncbi.nlm.nih.gov/33066380/ DOI: 10.3390/biom10101440","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"ETS consensus-site activity","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9bb5a1be-991c-5efb-9368-6790f7b30301","evidence_kind":"source_excerpt","locator":"Lines 99-108","start_line":99,"end_line":108,"excerpt":"## hericenones-erinacines-erinacine-c-ets\nErinacine C activated ETS-consensus transcription in parallel with, and independently of, neurotrophin induction in astrocytic reporter cells.\nModel/species: Astrocytic cells with transcriptional reporters\nTissue/system: ETS consensus-site activity\nExposure: Erinacine C concentration series\nRoute: In vitro\nDuration: Acute reporter assay\nLimits: Consensus reporter activity does not identify a single ETS-family protein or a human neural outcome.\nPrimary reference: Erinacine C Activates Transcription from a Consensus ETS DNA Binding Site in Astrocytic Cells in Addition to NGF Induction. (2020). https://pubmed.ncbi.nlm.nih.gov/33066380/ DOI: 10.3390/biom10101440\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Astrocytic cells with transcriptional reporters","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"aa7c09fd-ab4a-51ff-b463-d35547dc41ba","stable_key":"import-d39c4b36-9a88-5f52-8e6b-93a248dc4bfc","title":"Hericenones & Erinacines: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"f1ff2966f222f5c463e8e509ec1b1642a0053cd38f121f3847cdd21855c46e85","revision_id":"d00076e0-da87-5100-92ed-0525190b25a1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}