{"id":"f25cb6f2-98e8-55dd-bc8e-ed0f84ae87b8","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-marc-lipolysis","predicate":"loss_enhances","statement":"The protection required triglyceride breakdown through lipolysis and lipophagy, tested with Pnpla2 and Lipa inhibition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c1b63cc6-1b72-5fd8-96fe-c7f99e148a92","mechanism_event_label":"Fat had to be broken down for the protective effect to occur.","subject":{"id":"9a4caa98-09a8-5d90-a55a-40de766b54e1","slug":"mouse-mtarc1","display_name":"Mouse mitochondrial amidoxime-reducing component 1 / Mtarc1","entity_type_key":"protein"},"object":{"id":"181cfa2c-9f40-5ed2-a609-b13755b06a61","slug":"hepatic-lipid-droplet-degradation","display_name":"Hepatic lipid-droplet degradation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c1b63cc6-1b72-5fd8-96fe-c7f99e148a92","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-marc-lipolysis-event","event_type":"biochemical_relationship","label":"Fat had to be broken down for the protective effect to occur.","description":"The protection required triglyceride breakdown through lipolysis and lipophagy, tested with Pnpla2 and Lipa inhibition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59c3e39e-a4d7-5fe4-9325-800f99009992","slug":"mouse-pnpla2","display_name":"Mouse adipose triglyceride lipase / Pnpla2","entity_type_key":"protein"},"role":"lipolysis machinery","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4e69232e-3ea8-5a07-a01a-1309152ae65e","slug":"mouse-lipa","display_name":"Mouse lysosomal acid lipase / Lipa","entity_type_key":"protein"},"role":"lysosomal lipolysis machinery","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9a4caa98-09a8-5d90-a55a-40de766b54e1","slug":"mouse-mtarc1","display_name":"Mouse mitochondrial amidoxime-reducing component 1 / Mtarc1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"181cfa2c-9f40-5ed2-a609-b13755b06a61","slug":"hepatic-lipid-droplet-degradation","display_name":"Hepatic lipid-droplet degradation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/41641916.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"52b4d4d00867faaa1bb51ff6055f887a72c4c0d266bf7a1665b3780ce03aee64\", \"start_char\": 0, \"end_char\": 1681, \"text_sha256\": \"52b4d4d00867faaa1bb51ff6055f887a72c4c0d266bf7a1665b3780ce03aee64\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Global/liver Mtarc1 knockout with Pnpla2, Lipa, Pemt and Cept1 interventions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Diet-induced liver disease with gene knockouts/knockdowns and multi-omics","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preclinical mechanism; no evidence that dietary molybdenum restriction selectively reproduces MTARC1 targeting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus; supporting cell studies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Fat had to be broken down for the protective effect to occur.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p41641916] MTARC1 Inactivation Remodels Lipid Droplets to Protect Against Metabolic Fatty Liver Disease. (2026). https://pubmed.ncbi.nlm.nih.gov/41641916/ DOI: 10.1111/liv.70539","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hepatic lipid droplets","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b295cf06-7dcf-5342-b5dc-0623bed02aee","evidence_kind":"source_excerpt","locator":"Lines 1574-1585","start_line":1574,"end_line":1585,"excerpt":"### mo-marc-lipolysis\nThe protection required triglyceride breakdown through lipolysis and lipophagy, tested with Pnpla2 and Lipa inhibition.\nCondition category: machinery_impairment\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Fat had to be broken down for the protective effect to occur.\norganism: Mus musculus; supporting cell studies\ntissue_or_cell_type: Hepatic lipid droplets\nexperimental_model: Global/liver Mtarc1 knockout with Pnpla2, Lipa, Pemt and Cept1 interventions\nlimitations: Preclinical mechanism; no evidence that dietary molybdenum restriction selectively reproduces MTARC1 targeting.\nexposure: Diet-induced liver disease with gene knockouts/knockdowns and multi-omics\nevidence_span: {\"source_cache\": \"artifacts/molybdenum-research/41641916.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"52b4d4d00867faaa1bb51ff6055f887a72c4c0d266bf7a1665b3780ce03aee64\", \"start_char\": 0, \"end_char\": 1681, \"text_sha256\": \"52b4d4d00867faaa1bb51ff6055f887a72c4c0d266bf7a1665b3780ce03aee64\"}\n[mo-p41641916] MTARC1 Inactivation Remodels Lipid Droplets to Protect Against Metabolic Fatty Liver Disease. 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