{"id":"f2430c07-0fdd-598e-961a-3a519d05de56","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-lutein-auc","predicate":"reduces","statement":"Lutein AUC was reduced with the tested fibers, including pectin.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a62de9e5-b719-5398-9c46-3f829e11e13c","mechanism_event_label":"The finding also involved lutein.","subject":{"id":"5449346d-7614-5c4b-bbd2-03fb4dd71aeb","slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"},"object":{"id":"2d2c44d2-90fa-5efd-aef6-7c326ca09926","slug":"postmeal-lutein-response","display_name":"Human post-meal plasma lutein response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a62de9e5-b719-5398-9c46-3f829e11e13c","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-lutein-auc-event","event_type":"observed_intervention","label":"The finding also involved lutein.","description":"Lutein AUC was reduced with the tested fibers, including pectin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"role":"measured_substance","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5449346d-7614-5c4b-bbd2-03fb4dd71aeb","slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2d2c44d2-90fa-5efd-aef6-7c326ca09926","slug":"postmeal-lutein-response","display_name":"Human post-meal plasma lutein response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/10573545.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f0828162b0e41d10d79784cea5cc96e55409b4ee80be3afc399132a7ad087332\", \"start_char\": 0, \"end_char\": 1340, \"text_sha256\": \"f0828162b0e41d10d79784cea5cc96e55409b4ee80be3afc399132a7ad087332\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Crossover mixed-carotenoid meal study in six healthy women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Pectin or other fibers at 0.15 g/kg with a carotenoid and alpha-tocopherol mixture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reported effect-size ranges cover multiple fibers, not one pectin-specific estimate. Plasma exposure does not establish long-term deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The finding also involved lutein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p10573545] Some dietary fibers reduce the absorption of carotenoids in women. 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Plasma exposure does not establish long-term deficiency.\nexposure: Pectin or other fibers at 0.15 g/kg with a carotenoid and alpha-tocopherol mixture\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/10573545.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f0828162b0e41d10d79784cea5cc96e55409b4ee80be3afc399132a7ad087332\", \"start_char\": 0, \"end_char\": 1340, \"text_sha256\": \"f0828162b0e41d10d79784cea5cc96e55409b4ee80be3afc399132a7ad087332\"}\n[pectin-p10573545] Some dietary fibers reduce the absorption of carotenoids in women. (1999). https://pubmed.ncbi.nlm.nih.gov/10573545/ DOI: 10.1093/jn/129.12.2170","model_system":"Crossover mixed-carotenoid meal study in six healthy women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [pectin-p10573545] Some dietary fibers reduce the absorption of carotenoids in women. (1999). https://pubmed.ncbi.nlm.nih.gov/10573545/ DOI: 10.1093/jn/129.12.2170","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"13c3aae7-702f-5bc9-9fca-a57d141882ce","stable_key":"import-d17caac5-7018-5ca8-9e96-95afeb384bc4","title":"Pectin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff07001bc37d008a1e23fbba37146d0b0d33cc8c0bf42a75f1e1a7ef0aaeb489","revision_id":"76f1a2c5-02d0-511b-bde5-33079d7af6a0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}