{"id":"f2253b44-dee6-5ef4-ac0d-e569c443bbc5","stable_key":"2921131d-0ba0-51d3-8f59-8c4be3b9ac08:cucurbitacin-b-rat-absorption","predicate":"has_measured","statement":"Male Wistar rats receiving oral cucurbitacin B at 2–4 mg/kg versus intravenous 0.1 mg/kg had estimated oral bioavailability of about 10%, with oral peak around 30 minutes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"175ed6c1-cba0-5809-9eff-1be67efad0a3","mechanism_event_label":"Oral dose and systemic exposure were far from equivalent.","subject":{"id":"a544a561-7647-55f6-8ba1-c7ab0133f968","slug":"cucurbitacin-b","display_name":"Cucurbitacin B","entity_type_key":"small_molecule"},"object":{"id":"7f7ca1e7-bc47-5cf2-8eb9-69a0e77429cf","slug":"rat-cub-oral-bioavailability","display_name":"Rat cucurbitacin B oral bioavailability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"175ed6c1-cba0-5809-9eff-1be67efad0a3","stable_key":"2921131d-0ba0-51d3-8f59-8c4be3b9ac08:cucurbitacin-b-rat-absorption-event","event_type":"observed_relationship","label":"Oral dose and systemic exposure were far from equivalent.","description":"Male Wistar rats receiving oral cucurbitacin B at 2–4 mg/kg versus intravenous 0.1 mg/kg had estimated oral bioavailability of about 10%, with oral peak around 30 minutes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a544a561-7647-55f6-8ba1-c7ab0133f968","slug":"cucurbitacin-b","display_name":"Cucurbitacin B","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7f7ca1e7-bc47-5cf2-8eb9-69a0e77429cf","slug":"rat-cub-oral-bioavailability","display_name":"Rat cucurbitacin B oral bioavailability","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text PMC6609384","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat pharmacokinetics, six animals per reported group; clear solution in 40% v/v DMSO.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a human absorption estimate or dosing recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cucurbitacins collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cucurbitacin","display_name":"Cucurbitacins","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Oral dose and systemic exposure were far from equivalent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31272429/ · DOI 10.1186/s12906-019-2568-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"bf74827e-ee97-5ba4-ad80-547e9e38cce6","evidence_kind":"source_excerpt","locator":"Lines 348-354","start_line":348,"end_line":354,"excerpt":"## cucurbitacin-b-rat-absorption\nOral dose and systemic exposure were far from equivalent.\nMale Wistar rats receiving oral cucurbitacin B at 2–4 mg/kg versus intravenous 0.1 mg/kg had estimated oral bioavailability of about 10%, with oral peak around 30 minutes.\nModel: Rat pharmacokinetics, six animals per reported group; clear solution in 40% v/v DMSO.\nLimitations: Not a human absorption estimate or dosing recommendation.\nEvidence access: Primary full text PMC6609384\nPharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31272429/ · DOI 10.1186/s12906-019-2568-7","model_system":"Rat pharmacokinetics, six animals per reported group; clear solution in 40% v/v DMSO.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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