{"id":"f2209122-ef20-5072-9de8-19493196517f","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-rebd-bile","predicate":"is_associated_with","statement":"Rebaudioside D treatment was associated with greater secondary bile-acid metabolism and enrichment of Faecalibaculum rodentium in the same mouse experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"663983a6-024f-58c4-adfa-a8c1d6ab268c","mechanism_event_label":"Microbial chemistry is a candidate link to the liver response.","subject":{"id":"f6c3869b-5049-52d8-b31d-98bfd421ebf4","slug":"rebaudioside-d","display_name":"Rebaudioside D","entity_type_key":"small_molecule"},"object":{"id":"234000d9-6586-5e48-a17e-b17645a2263f","slug":"mouse-rebd-secondary-bile-acid-metabolism","display_name":"Mouse rebaudioside-D-associated secondary bile-acid metabolism","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"663983a6-024f-58c4-adfa-a8c1d6ab268c","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-rebd-bile-event","event_type":"observed_relationship","label":"Microbial chemistry is a candidate link to the liver response.","description":"Rebaudioside D treatment was associated with greater secondary bile-acid metabolism and enrichment of Faecalibaculum rodentium in the same mouse experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f6c3869b-5049-52d8-b31d-98bfd421ebf4","slug":"rebaudioside-d","display_name":"Rebaudioside D","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"234000d9-6586-5e48-a17e-b17645a2263f","slug":"mouse-rebd-secondary-bile-acid-metabolism","display_name":"Mouse rebaudioside-D-associated secondary bile-acid metabolism","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fecal metagenomics and bile-acid measurements in feces, plasma and liver.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association does not prove the microbe or bile acids caused the hepatic effect; neither glycoside improved glucose homeostasis in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Microbial chemistry is a candidate link to the liver response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Rebaudioside D decreases adiposity and hepatic lipid accumulation in a mouse model of obesity. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38321177/ · DOI 10.1038/s41598-024-53587-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5da990a9-8935-58c5-bfa4-204c229c505a","evidence_kind":"source_excerpt","locator":"Lines 426-432","start_line":426,"end_line":432,"excerpt":"## stevia-rebd-bile\nMicrobial chemistry is a candidate link to the liver response.\nRebaudioside D treatment was associated with greater secondary bile-acid metabolism and enrichment of Faecalibaculum rodentium in the same mouse experiment.\nModel: Fecal metagenomics and bile-acid measurements in feces, plasma and liver.\nLimitations: Association does not prove the microbe or bile acids caused the hepatic effect; neither glycoside improved glucose homeostasis in this study.\nEvidence access: Primary abstract\nRebaudioside D decreases adiposity and hepatic lipid accumulation in a mouse model of obesity. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38321177/ · DOI 10.1038/s41598-024-53587-y","model_system":"Fecal metagenomics and bile-acid measurements in feces, plasma and liver.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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