{"id":"f1cf9f6f-92d8-5f21-87ff-63e1420fb91a","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-diet-brain-mda","predicate":"deficiency-increases","statement":"Chronically vitamin-C-restricted guinea pigs had higher brain malondialdehyde than vitamin-C-sufficient controls at day 70.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"68241d1d-2d85-5fc2-bc80-cea1a0b7009a","mechanism_event_label":"Low vitamin C increased a marker of brain lipid oxidation.","subject":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"object":{"id":"b8bfb98f-b9e6-5093-8745-d35be77c1404","slug":"brain-malondialdehyde-content","display_name":"Brain malondialdehyde content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"68241d1d-2d85-5fc2-bc80-cea1a0b7009a","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-diet-brain-mda-event","event_type":"observed_intervention","label":"Low vitamin C increased a marker of brain lipid oxidation.","description":"Chronically vitamin-C-restricted guinea pigs had higher brain malondialdehyde than vitamin-C-sufficient controls at day 70.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"process indexed by MDA","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b8bfb98f-b9e6-5093-8745-d35be77c1404","slug":"brain-malondialdehyde-content","display_name":"Brain malondialdehyde content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Thirty female guinea pig offspring, control/deficient/repleted diets, postnatal day 70","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Prenatal/postnatal 100/100 mg vitamin C/kg diet versus 900/750 mg/kg controls; female offspring at day 70","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"An oxidative marker does not measure every developmental or neurological outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cavia porcellus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Low vitamin C increased a marker of brain lipid oxidation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[brain2014] Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. (2014). https://pubmed.ncbi.nlm.nih.gov/24787032/ DOI: 10.3390/nu6051809","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c6d336c6-9d4a-57e7-8213-e9052f2d1875","evidence_kind":"source_excerpt","locator":"Lines 494-505","start_line":494,"end_line":505,"excerpt":"### vc-transport-diet-brain-mda\nChronically vitamin-C-restricted guinea pigs had higher brain malondialdehyde than vitamin-C-sufficient controls at day 70.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Low vitamin C increased a marker of brain lipid oxidation.\norganism: Cavia porcellus\ntissue_or_cell_type: Brain\nexperimental_model: Thirty female guinea pig offspring, control/deficient/repleted diets, postnatal day 70\nlimitations: An oxidative marker does not measure every developmental or neurological outcome.\nexposure: Prenatal/postnatal 100/100 mg vitamin C/kg diet versus 900/750 mg/kg controls; female offspring at day 70\ncross_nutrient: false\n[brain2014] Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. 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