{"id":"f195eb1c-ecf5-5304-846d-c8cd30545584","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-burt-radius","predicate":"lowers-at-higher-doses","statement":"Relative to 400 IU/day, final radial volumetric BMD was lower by 3.9 mgHA/cm³ with 4000 IU (95% CI−6.5 to−1.3) and 7.5 mgHA/cm³ with 10000 IU (CI−10.1 to−5.0).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b6ee8bed-1883-5638-83d2-a134d57fcd8b","mechanism_event_label":"More vitamin D did not produce denser bone at the forearm in this trial.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"f0f61f72-c958-582b-8a66-80d17afaff36","slug":"radial-volumetric-bone-mineral-density","display_name":"Radial volumetric bone mineral density","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b6ee8bed-1883-5638-83d2-a134d57fcd8b","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-burt-radius-event","event_type":"observed_intervention","label":"More vitamin D did not produce denser bone at the forearm in this trial.","description":"Relative to 400 IU/day, final radial volumetric BMD was lower by 3.9 mgHA/cm³ with 4000 IU (95% CI−6.5 to−1.3) and 7.5 mgHA/cm³ with 10000 IU (CI−10.1 to−5.0).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"conditional-cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f0f61f72-c958-582b-8a66-80d17afaff36","slug":"radial-volumetric-bone-mineral-density","display_name":"Radial volumetric bone mineral density","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"311 healthy adults 55–70 randomized to daily 400, 4000, 10000 IU D3 for 3 years; 287 completed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"D3 400, 4000 or 10000 IU/day for 3 years; calcium added for dietary intake<1200 mg/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Adults without osteoporosis, baseline 25(OH)D30–125 nmol/L; surrogate outcomes, not a deficiency-repletion trial or fracture endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More vitamin D did not produce denser bone at the forearm in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[burt2019] Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31454046/ DOI: 10.1001/jama.2019.11889","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Radius","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6e9e40fd-174b-543b-b059-7b29f1474916","evidence_kind":"source_excerpt","locator":"Lines 1600-1611","start_line":1600,"end_line":1611,"excerpt":"### vd-burt-radius\nRelative to 400 IU/day, final radial volumetric BMD was lower by 3.9 mgHA/cm³ with 4000 IU (95% CI−6.5 to−1.3) and 7.5 mgHA/cm³ with 10000 IU (CI−10.1 to−5.0).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More vitamin D did not produce denser bone at the forearm in this trial.\norganism: Homo sapiens\ntissue_or_cell_type: Radius\nexperimental_model: 311 healthy adults 55–70 randomized to daily 400, 4000, 10000 IU D3 for 3 years; 287 completed\nlimitations: Adults without osteoporosis, baseline 25(OH)D30–125 nmol/L; surrogate outcomes, not a deficiency-repletion trial or fracture endpoint.\nexposure: D3 400, 4000 or 10000 IU/day for 3 years; calcium added for dietary intake<1200 mg/day.\ncross_nutrient: true\n[burt2019] Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. 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