{"id":"f1889287-6a16-5525-a978-31cf40b00371","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-adeno","predicate":"supports_lpo_dependent_inactivation","statement":"Replacing thiocyanate with iodide in the LPO/H2O2 system reduced adenovirus transduction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"086bc5b4-6312-5a44-bc82-a2274896026d","mechanism_event_label":"Changing the enzyme substrate changed antiviral activity.","subject":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"object":{"id":"283b1ada-16c0-5fd1-b072-3efe9c034c5e","slug":"adenovirus-transduction","display_name":"Adenovirus transduction","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"086bc5b4-6312-5a44-bc82-a2274896026d","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-adeno-event","event_type":"observed_relationship","label":"Changing the enzyme substrate changed antiviral activity.","description":"Replacing thiocyanate with iodide in the LPO/H2O2 system reduced adenovirus transduction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"283b1ada-16c0-5fd1-b072-3efe9c034c5e","slug":"adenovirus-transduction","display_name":"Adenovirus transduction","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3d671567-4fb6-5b5f-a328-156987d5b396","slug":"lactoperoxidase-family","display_name":"Lactoperoxidase enzyme family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5d54e0a3-869f-5132-82c9-4c0ff47cd400","slug":"thiocyanate-ion","display_name":"Thiocyanate ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Culture antiviral activity and human secretion measurements do not establish prevention or treatment of human infection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Changing the enzyme substrate changed antiviral activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21441383/ · DOI 10.1165/rcmb.2010-0329oc","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f5063cf6-ddc2-50ef-891d-a7a147b95947","evidence_kind":"source_excerpt","locator":"Lines 72-78","start_line":72,"end_line":78,"excerpt":"## ki-air-adeno\nChanging the enzyme substrate changed antiviral activity.\nReplacing thiocyanate with iodide in the LPO/H2O2 system reduced adenovirus transduction.\nModel: Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms.\nLimitations: Culture antiviral activity and human secretion measurements do not establish prevention or treatment of human infection.\nEvidence location: Primary abstract\nEnhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21441383/ · DOI 10.1165/rcmb.2010-0329oc","model_system":"Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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