{"id":"f16e0cc7-cb38-5844-8248-44d45de54d73","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-osteoblast-activity","predicate":"increases","statement":"Hyperbaric oxygen increased osteoblastic activity in irradiated distracted bone and shifted the osteogenic pattern towards that of non-irradiated bone, though not to the level of non-irradiated bone.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"528882ef-72e8-5fb7-b5a6-bf4a07725a5b","mechanism_event_label":"Irradiated bone rebuilt more like healthy bone, without fully catching up.","subject":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"object":{"id":"b07b7229-bbbf-5426-bbb0-30f438fd8a22","slug":"osteoblastic-activity","display_name":"Osteoblastic activity in distracted bone","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"528882ef-72e8-5fb7-b5a6-bf4a07725a5b","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-osteoblast-activity-event","event_type":"biochemical_relationship","label":"Irradiated bone rebuilt more like healthy bone, without fully catching up.","description":"Hyperbaric oxygen increased osteoblastic activity in irradiated distracted bone and shifted the osteogenic pattern towards that of non-irradiated bone, though not to the level of non-irradiated bone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d49568fd-7020-51a7-b7c8-9dc8386cfb02","slug":"osteoblast","display_name":"Osteoblast","entity_type_key":"cell_type"},"role":"affected_cell","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b07b7229-bbbf-5426-bbb0-30f438fd8a22","slug":"osteoblastic-activity","display_name":"Osteoblastic activity in distracted bone","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/hbot-research/15050074.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1fe4a8f81ae5308f452c7a4551e9de0f0426daf32cbcd153149ec6e6a7a61970\", \"start_char\": 0, \"end_char\": 1615, \"text_sha256\": \"1fe4a8f81ae5308f452c7a4551e9de0f0426daf32cbcd153149ec6e6a7a61970\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Irradiated and non-irradiated rabbit mandibular distraction osteogenesis with fluoride autoradiography","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2.5 ATA for 90 minutes daily, 18 sessions preoperatively, after 22.4 Gy irradiation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A pre-treatment protocol in irradiated bone. 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Osteoblastic activity was measured by fluoride uptake, an activity surrogate.\nexposure: 2.5 ATA for 90 minutes daily, 18 sessions preoperatively, after 22.4 Gy irradiation\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/15050074.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1fe4a8f81ae5308f452c7a4551e9de0f0426daf32cbcd153149ec6e6a7a61970\", \"start_char\": 0, \"end_char\": 1615, \"text_sha256\": \"1fe4a8f81ae5308f452c7a4551e9de0f0426daf32cbcd153149ec6e6a7a61970\"}\n[hbot-p15050074] Osteoblastic activity and neoangiogenesis in distracted bone of irradiated rabbit mandible with or without hyperbaric oxygen treatment. 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