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depolarizing Kir4.1 mutants increased it.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A change outside the cell can change chloride inside, connecting potassium sensing to salt transport.\norganism: Homo sapiens; Mus musculus cell lines\ntissue_or_cell_type: HEK293 and mDCT cells\nexperimental_model: Cell culture and Kir4.1 mutant comparisons\nlimitations: HEK chloride and WNK expression differ from native DCT.\ncross_nutrient: Extracellular K controls the intracellular chloride signal.\nevidence_location: Figure 6A-B; Figure S5.\n[terker-2015-k-voltage-chloride] Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4332769/ DOI: 10.1016/j.cmet.2014.12.006","model_system":"Cell culture and Kir4.1 mutant comparisons","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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