{"id":"f0e582e4-19c3-5ad1-9c05-5b6b5c03290b","stable_key":"d40a4478-67a9-5bdf-b7a2-eb7d17e24dd7:iodine-export-2016-efflux","predicate":"increases","statement":"Iodide pretreatment for 12, 24 and 48 hours increased fractional radioiodide efflux despite reduced iodide uptake.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"06e976b7-d1dc-5b79-a856-52d31908737e","mechanism_event_label":"Iodide pretreatment for 12, 24 and 48 hours increased fractional radioiodide efflux despite reduced iodide uptake.","subject":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"object":{"id":"99611171-98f5-5310-af88-a988e8f0e6a6","slug":"cellular-iodide-efflux","display_name":"Cellular iodide efflux","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"06e976b7-d1dc-5b79-a856-52d31908737e","stable_key":"d40a4478-67a9-5bdf-b7a2-eb7d17e24dd7:iodine-export-2016-efflux-event","event_type":"observed_intervention","label":"Iodide pretreatment for 12, 24 and 48 hours increased fractional radioiodide efflux despite reduced iodide uptake.","description":"Iodide pretreatment for 12, 24 and 48 hours increased fractional radioiodide efflux despite reduced iodide uptake.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"exposure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"99611171-98f5-5310-af88-a988e8f0e6a6","slug":"cellular-iodide-efflux","display_name":"Cellular iodide efflux","entity_type_key":"cellular_process"},"role":"measured_target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Rat thyroid PCCl3 cells; 1 mM NaI unless specified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Experimental iodide excess; normal is the schema category outside deficiency, machinery impairment and biomarker context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Nonpolarized cells; concurrent changes do not establish pendrin necessity, human protection, or an intake threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"measurement","value_text":"Radioiodide release; perchlorate blocked reuptake; Figure 5B.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"primary_references","value_text":"Calil-Silveira et al. (2016). Iodide excess regulates its own efflux: a possible involvement of pendrin. DOI: 10.1152/ajpcell.00210.2015. https://pubmed.ncbi.nlm.nih.gov/26791486/","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9a61c30f-db06-5572-9ed1-7ac8d53c029e","evidence_kind":"source_excerpt","locator":"Lines 21-23","start_line":21,"end_line":23,"excerpt":"## efflux\nIodide pretreatment for 12, 24 and 48 hours increased fractional radioiodide efflux despite reduced iodide uptake.\nMeasurement: Radioiodide release; perchlorate blocked reuptake; Figure 5B.","model_system":"Rat thyroid PCCl3 cells; 1 mM NaI unless specified.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact curation-document span. Primary study paraphrased; no independent replication implied.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2b88cda3-3556-5f62-b7f5-b12270e6f766","stable_key":"import-d40a4478-67a9-5bdf-b7a2-eb7d17e24dd7","title":"Iodine addendum: iodide excess and cellular export (2026-09-18)","document_type":"imported_text","citation_label":"Calil-Silveira et al. (2016). Iodide excess regulates its own efflux: a possible involvement of pendrin. DOI: 10.1152/ajpcell.00210.2015. https://pubmed.ncbi.nlm.nih.gov/26791486/","file_path":"","sha256":"329cc12a4aaa7d6ccaeca0e5c1ffa3e447ef2debd046fc2bcd9e4f3ae33a13b3","revision_id":"93964ea3-ead3-50bb-ad49-c05a425f73d8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}