{"id":"f0c315ce-ba43-5eea-a74f-dc2dfd29d9c8","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-proteome","predicate":"changes","statement":"A seven-day fast changed more than 1,000 measured plasma proteins; broad changes became evident after about three days.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"71ec49ca-75e7-5e1e-94ce-3a6dc85a1158","mechanism_event_label":"Many circulating proteins adapted, on different schedules.","subject":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"object":{"id":"05b7b1b7-5611-50ec-b4b4-b9b1bee948e0","slug":"fasting-plasma-proteome-remodeling","display_name":"Plasma proteome changes during fasting","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"71ec49ca-75e7-5e1e-94ce-3a6dc85a1158","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-proteome-event","event_type":"observed_relationship","label":"Many circulating proteins adapted, on different schedules.","description":"A seven-day fast changed more than 1,000 measured plasma proteins; broad changes became evident after about three days.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"05b7b1b7-5611-50ec-b4b4-b9b1bee948e0","slug":"fasting-plasma-proteome-remodeling","display_name":"Plasma proteome changes during fasting","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve volunteers; approximately 3,000 plasma proteins profiled.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Three days is not an autophagy-onset threshold. Proteogenomic disease predictions are not observed clinical outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Many circulating proteins adapted, on different schedules.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Systemic proteome adaptions to 7-day complete caloric restriction in humans. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38429390/ · DOI 10.1038/s42255-024-01008-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"486a1297-164b-5860-a6be-bd2909439519","evidence_kind":"source_excerpt","locator":"Lines 416-422","start_line":416,"end_line":422,"excerpt":"## fast-proteome\nMany circulating proteins adapted, on different schedules.\nA seven-day fast changed more than 1,000 measured plasma proteins; broad changes became evident after about three days.\nModel: Twelve volunteers; approximately 3,000 plasma proteins profiled.\nLimitations: Three days is not an autophagy-onset threshold. Proteogenomic disease predictions are not observed clinical outcomes.\nEvidence access: Primary abstract\nSystemic proteome adaptions to 7-day complete caloric restriction in humans. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38429390/ · DOI 10.1038/s42255-024-01008-9","model_system":"Twelve volunteers; approximately 3,000 plasma proteins profiled.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}