{"id":"f085f8a9-b637-53fc-99e8-bbd278744593","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-low-diet-fat-2023","predicate":"low_intake_increases","statement":"The low-chromium group consumed more energy later in the experiment and accumulated more body fat than the normal-chromium group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"fe188d15-75cd-5563-840d-9b201a31555e","mechanism_event_label":"The result involved food intake and body composition as well as glucose-related measurements.","subject":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"object":{"id":"e8e74957-1698-585e-9e88-5a340a7899d1","slug":"whole-body-fat-mass","display_name":"Whole-body fat mass","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fe188d15-75cd-5563-840d-9b201a31555e","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-low-diet-fat-2023-event","event_type":"observed_intervention","label":"The result involved food intake and body composition as well as glucose-related measurements.","description":"The low-chromium group consumed more energy later in the experiment and accumulated more body fat than the normal-chromium group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e8e74957-1698-585e-9e88-5a340a7899d1","slug":"whole-body-fat-mass","display_name":"Whole-body fat mass","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/36701335.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"762bdd075019b97831308c39060063214abcb5c5075bfc69afd9b1e250b41a48\", \"start_char\": 0, \"end_char\": 1806, \"text_sha256\": \"762bdd075019b97831308c39060063214abcb5c5075bfc69afd9b1e250b41a48\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve-week dietary chromium experiment in both sexes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"From day 35 of age; moderately high-fat/high-sucrose diets with 0.33, 1.20 or 9.15 mg Cr/kg; 10 males and 10 females/group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different diet, strain and duration from the 2011 study. Greater food intake can contribute to adiposity and insulin changes. Low is relative to this rodent formulation, not a human deficiency cutoff.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Sprague-Dawley CD rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The result involved food intake and body composition as well as glucose-related measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p36701335] A low chromium diet increases body fat, energy intake and circulating triglycerides and insulin in male and female rats fed a moderately high-fat, high-sucrose diet from peripuberty to young adult age. (2023). https://pubmed.ncbi.nlm.nih.gov/36701335/ DOI: 10.1371/journal.pone.0281019","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-body fat and circulating metabolic measures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"aaa8a72a-1684-5899-904d-fffc6c92eb70","evidence_kind":"source_excerpt","locator":"Lines 991-1002","start_line":991,"end_line":1002,"excerpt":"### chromium-low-diet-fat-2023\nThe low-chromium group consumed more energy later in the experiment and accumulated more body fat than the normal-chromium group.\nCondition category: nutrient_deficiency\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The result involved food intake and body composition as well as glucose-related measurements.\norganism: Sprague-Dawley CD rats\ntissue_or_cell_type: Whole-body fat and circulating metabolic measures\nexperimental_model: Twelve-week dietary chromium experiment in both sexes\nlimitations: Different diet, strain and duration from the 2011 study. Greater food intake can contribute to adiposity and insulin changes. Low is relative to this rodent formulation, not a human deficiency cutoff.\nexposure: From day 35 of age; moderately high-fat/high-sucrose diets with 0.33, 1.20 or 9.15 mg Cr/kg; 10 males and 10 females/group\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/36701335.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"762bdd075019b97831308c39060063214abcb5c5075bfc69afd9b1e250b41a48\", \"start_char\": 0, \"end_char\": 1806, \"text_sha256\": \"762bdd075019b97831308c39060063214abcb5c5075bfc69afd9b1e250b41a48\"}\n[chromium-p36701335] A low chromium diet increases body fat, energy intake and circulating triglycerides and insulin in male and female rats fed a moderately high-fat, high-sucrose diet from peripuberty to young adult age. (2023). https://pubmed.ncbi.nlm.nih.gov/36701335/ DOI: 10.1371/journal.pone.0281019","model_system":"Twelve-week dietary chromium experiment in both sexes","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chromium-p36701335] A low chromium diet increases body fat, energy intake and circulating triglycerides and insulin in male and female rats fed a moderately high-fat, high-sucrose diet from peripuberty to young adult age. (2023). https://pubmed.ncbi.nlm.nih.gov/36701335/ DOI: 10.1371/journal.pone.0281019","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa96342a-ca01-5425-98d9-d50e29bf0abd","stable_key":"import-4d8e4781-3878-5818-8d0a-7dbd6e024555","title":"Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"6cae22f9104c6de041b25c23b0fd2884cc57707ac0c9a87c20b0e665d16de5ab","revision_id":"22893798-8329-5295-9c9d-82169032fc79","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}