{"id":"f0723f1b-da08-5712-bee5-7d522f480f46","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-kidney-glucose","predicate":"increases_contribution","statement":"Estimated renal contribution to whole-body glucose production increased from 5 ± 2% postabsorptively to 24 ± 3% after 60 hours.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e86dd7a6-a8a3-52d4-b38f-09a2cc5fbb89","mechanism_event_label":"The kidney helped make glucose, alongside the liver.","subject":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"object":{"id":"cfebcd43-f5b9-5edd-9eef-e35d238e64cf","slug":"renal-glucose-production","display_name":"Renal glucose production","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e86dd7a6-a8a3-52d4-b38f-09a2cc5fbb89","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-kidney-glucose-event","event_type":"observed_relationship","label":"The kidney helped make glucose, alongside the liver.","description":"Estimated renal contribution to whole-body glucose production increased from 5 ± 2% postabsorptively to 24 ± 3% after 60 hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cfebcd43-f5b9-5edd-9eef-e35d238e64cf","slug":"renal-glucose-production","display_name":"Renal glucose production","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy humans; renal/hepatic exchange and isotope measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study-specific estimates, not a universal organ split.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"The kidney helped make glucose, alongside the liver.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10334304/ · DOI 10.2337/diabetes.48.2.292","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4e609581-9443-573a-a735-d9ee84a8fbea","evidence_kind":"source_excerpt","locator":"Lines 80-86","start_line":80,"end_line":86,"excerpt":"## fast-kidney-glucose\nThe kidney helped make glucose, alongside the liver.\nEstimated renal contribution to whole-body glucose production increased from 5 ± 2% postabsorptively to 24 ± 3% after 60 hours.\nModel: Healthy humans; renal/hepatic exchange and isotope measurements.\nLimitations: Study-specific estimates, not a universal organ split.\nEvidence access: Primary abstract\nContributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10334304/ · DOI 10.2337/diabetes.48.2.292","model_system":"Healthy humans; renal/hepatic exchange and isotope measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}