{"id":"f06d0f08-b555-5c91-a40c-f10c8e6fb4e5","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-imp-mouse-tolerance","predicate":"impairs_tested","statement":"Administering imidazole propionate impaired glucose tolerance in the reported mouse experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3254d47f-e109-53f3-ad4c-4fd7bbf12d10","mechanism_event_label":"Giving the microbial product affected glucose control in an animal experiment.","subject":{"id":"06c093ed-025c-54bc-8016-6a3da64ffbf9","slug":"imidazole-propionate","display_name":"Imidazole propionate","entity_type_key":"small_molecule"},"object":{"id":"c78508b9-7240-5fbf-b9a9-4038cc7d5a0c","slug":"mouse-imp-glucose-tolerance","display_name":"Glucose tolerance after imidazole-propionate administration in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3254d47f-e109-53f3-ad4c-4fd7bbf12d10","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-imp-mouse-tolerance-event","event_type":"observed_relationship","label":"Giving the microbial product affected glucose control in an animal experiment.","description":"Administering imidazole propionate impaired glucose tolerance in the reported mouse experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06c093ed-025c-54bc-8016-6a3da64ffbf9","slug":"imidazole-propionate","display_name":"Imidazole propionate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c78508b9-7240-5fbf-b9a9-4038cc7d5a0c","slug":"mouse-imp-glucose-tolerance","display_name":"Glucose tolerance after imidazole-propionate administration in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse metabolite-administration study; dose details not extracted from accessed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a dietary-histidine intervention or a demonstrated human clinical effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Giving the microbial product affected glucose control in an animal experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30401435/ · DOI 10.1016/j.cell.2018.09.055","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e6812980-cbdd-57a4-8e06-735f4dade5e2","evidence_kind":"source_excerpt","locator":"Lines 298-304","start_line":298,"end_line":304,"excerpt":"## histidine-imp-mouse-tolerance\nGiving the microbial product affected glucose control in an animal experiment.\nAdministering imidazole propionate impaired glucose tolerance in the reported mouse experiments.\nModel: Mouse metabolite-administration study; dose details not extracted from accessed primary abstract.\nLimitations: Not a dietary-histidine intervention or a demonstrated human clinical effect.\nEvidence access: Primary abstract\nMicrobially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30401435/ · DOI 10.1016/j.cell.2018.09.055","model_system":"Mouse metabolite-administration study; dose details not extracted from accessed primary abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"cb672530ec8b4a4542d0f3957e80ca76bb0449e9f988845b0f7681f623c4ec9b","revision_id":"19a7f26c-d9a1-5411-a81d-025f3d98a452","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}